Use of principal component analysis for the study of the retention behaviour of anticancer drugs on a β-cyclodextrin polymer-coated silica column

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Abstract

The retention parameters of eighteen commercial anticancer drugs were determined on a β-cyclodextrin polymer-coated silica support (βCDP) using methanol-water mixtures as eluent and the relationship between the retention behaviour and physico-chemical parameters was elucidated by principal component analysis (PCA) followed by two-dimensional non-linear mapping. No significant linear correlation was found between the retention behaviour of drugs on octadecylsilica and βCDP silica columns, indicating that the retention capacity and selectivity of the columns are considerably different. The results of PCA indicated that hydrophobic and electronic interactions and steric conditions govern the retention of anticancer drugs on βCDP column, suggesting a mixed retention mechanism.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalJournal of Chromatography A
Volume728
Issue number1-2
Publication statusPublished - Mar 29 1996

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Cytidine Diphosphate
Principal Component Analysis
Silicon Dioxide
Principal component analysis
Pharmaceutical Preparations
Hydrophobic and Hydrophilic Interactions
Methanol
Water
cyclodextrin polymer

Keywords

  • Cyclodextrin polymer-coated columns
  • Cyclodextrins
  • Drugs
  • Principal component analysis
  • Retention behaviour
  • Stationary phases, LC

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

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abstract = "The retention parameters of eighteen commercial anticancer drugs were determined on a β-cyclodextrin polymer-coated silica support (βCDP) using methanol-water mixtures as eluent and the relationship between the retention behaviour and physico-chemical parameters was elucidated by principal component analysis (PCA) followed by two-dimensional non-linear mapping. No significant linear correlation was found between the retention behaviour of drugs on octadecylsilica and βCDP silica columns, indicating that the retention capacity and selectivity of the columns are considerably different. The results of PCA indicated that hydrophobic and electronic interactions and steric conditions govern the retention of anticancer drugs on βCDP column, suggesting a mixed retention mechanism.",
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AU - Forgács, E.

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N2 - The retention parameters of eighteen commercial anticancer drugs were determined on a β-cyclodextrin polymer-coated silica support (βCDP) using methanol-water mixtures as eluent and the relationship between the retention behaviour and physico-chemical parameters was elucidated by principal component analysis (PCA) followed by two-dimensional non-linear mapping. No significant linear correlation was found between the retention behaviour of drugs on octadecylsilica and βCDP silica columns, indicating that the retention capacity and selectivity of the columns are considerably different. The results of PCA indicated that hydrophobic and electronic interactions and steric conditions govern the retention of anticancer drugs on βCDP column, suggesting a mixed retention mechanism.

AB - The retention parameters of eighteen commercial anticancer drugs were determined on a β-cyclodextrin polymer-coated silica support (βCDP) using methanol-water mixtures as eluent and the relationship between the retention behaviour and physico-chemical parameters was elucidated by principal component analysis (PCA) followed by two-dimensional non-linear mapping. No significant linear correlation was found between the retention behaviour of drugs on octadecylsilica and βCDP silica columns, indicating that the retention capacity and selectivity of the columns are considerably different. The results of PCA indicated that hydrophobic and electronic interactions and steric conditions govern the retention of anticancer drugs on βCDP column, suggesting a mixed retention mechanism.

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