Use of principal component analysis for the evaluation of the retention behaviour of monoamine oxidase inhibitory drugs on β-cyclodextrin column

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Abstract

The retention of 17 monoamine oxidase inhibitory drugs (proparlgylamine derivatives) were determined on a β-cyclodextrin polymer (βCDP)-coated silica column using ethanol-0.05 M K2HPO4 (6:4 v/v) as the eluent. The relative strength of interaction between the drugs and a water soluble β-cycodextrin polymer was determined by charge-transfer chromatography carried out on reversed-phase TLC layers. The relationship between capacity factors, physicochemical parameters and inclusion complex forming capacity of the monoamine oxidase inhibitory drugs were evaluated by stepwise regrerssion analysis and by principal component analysis (PCA) followed by two-dimensional nonlinear mapping and varimax rotation. Calculations indicated that the retention of monoamine oxidase inhibitory drugs on βCDP column is mainly governed by their steric and lipophylic parameters. Significant linear correlations were found between the corresponding coordinates of varimax rotation and two-dimensional nonlinear maps proving the suitability of both methods for the reduction of dimensionality of complicated data matrices.

Original languageEnglish
Pages (from-to)525-532
Number of pages8
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume13
Issue number4-5
DOIs
Publication statusPublished - 1995

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Monoamine Oxidase
Cyclodextrins
Principal Component Analysis
Principal component analysis
Pharmaceutical Preparations
Drug Interactions
Silicon Dioxide
Chromatography
Polymers
Ethanol
Charge transfer
Water
Derivatives
cyclodextrin polymer

Keywords

  • principal component analysis
  • varimax rotation
  • β-cyclodextrin coated silica

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Drug Discovery
  • Pharmaceutical Science

Cite this

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title = "Use of principal component analysis for the evaluation of the retention behaviour of monoamine oxidase inhibitory drugs on β-cyclodextrin column",
abstract = "The retention of 17 monoamine oxidase inhibitory drugs (proparlgylamine derivatives) were determined on a β-cyclodextrin polymer (βCDP)-coated silica column using ethanol-0.05 M K2HPO4 (6:4 v/v) as the eluent. The relative strength of interaction between the drugs and a water soluble β-cycodextrin polymer was determined by charge-transfer chromatography carried out on reversed-phase TLC layers. The relationship between capacity factors, physicochemical parameters and inclusion complex forming capacity of the monoamine oxidase inhibitory drugs were evaluated by stepwise regrerssion analysis and by principal component analysis (PCA) followed by two-dimensional nonlinear mapping and varimax rotation. Calculations indicated that the retention of monoamine oxidase inhibitory drugs on βCDP column is mainly governed by their steric and lipophylic parameters. Significant linear correlations were found between the corresponding coordinates of varimax rotation and two-dimensional nonlinear maps proving the suitability of both methods for the reduction of dimensionality of complicated data matrices.",
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T1 - Use of principal component analysis for the evaluation of the retention behaviour of monoamine oxidase inhibitory drugs on β-cyclodextrin column

AU - Forgács, E.

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N2 - The retention of 17 monoamine oxidase inhibitory drugs (proparlgylamine derivatives) were determined on a β-cyclodextrin polymer (βCDP)-coated silica column using ethanol-0.05 M K2HPO4 (6:4 v/v) as the eluent. The relative strength of interaction between the drugs and a water soluble β-cycodextrin polymer was determined by charge-transfer chromatography carried out on reversed-phase TLC layers. The relationship between capacity factors, physicochemical parameters and inclusion complex forming capacity of the monoamine oxidase inhibitory drugs were evaluated by stepwise regrerssion analysis and by principal component analysis (PCA) followed by two-dimensional nonlinear mapping and varimax rotation. Calculations indicated that the retention of monoamine oxidase inhibitory drugs on βCDP column is mainly governed by their steric and lipophylic parameters. Significant linear correlations were found between the corresponding coordinates of varimax rotation and two-dimensional nonlinear maps proving the suitability of both methods for the reduction of dimensionality of complicated data matrices.

AB - The retention of 17 monoamine oxidase inhibitory drugs (proparlgylamine derivatives) were determined on a β-cyclodextrin polymer (βCDP)-coated silica column using ethanol-0.05 M K2HPO4 (6:4 v/v) as the eluent. The relative strength of interaction between the drugs and a water soluble β-cycodextrin polymer was determined by charge-transfer chromatography carried out on reversed-phase TLC layers. The relationship between capacity factors, physicochemical parameters and inclusion complex forming capacity of the monoamine oxidase inhibitory drugs were evaluated by stepwise regrerssion analysis and by principal component analysis (PCA) followed by two-dimensional nonlinear mapping and varimax rotation. Calculations indicated that the retention of monoamine oxidase inhibitory drugs on βCDP column is mainly governed by their steric and lipophylic parameters. Significant linear correlations were found between the corresponding coordinates of varimax rotation and two-dimensional nonlinear maps proving the suitability of both methods for the reduction of dimensionality of complicated data matrices.

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KW - varimax rotation

KW - β-cyclodextrin coated silica

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