Use of isoptin for counteracting the effect of methol on cardiac activity in experimental animals

Jánus Domahidi, Katica Péter, J. Farkas

Research output: Contribution to journalArticle

Abstract

The purpose of the present study is to use isoptin in order to lower intracellular Ca2+ concentration for counteracting the effect of methol on cardiac activity in acute intoxication of the experimental animals. Adult male Wistar rats were used - 8 animals/lot anaesthesized with urethan. ECG activity was recorded every 15 minutes, for 360 minutes. Administration (oral) of methol in a dose of 310 mg/kg/bw. (DL100) produced sinusal bradycardia, which became more marked later on. Isoptin administration in a dose of 5 mg/kg/bw. in rats with 310 mg/kg/bw. methol decreased the heart rate, the lowest value occurring 120 minutes after administration, followed by a slow increase until the end of the recording. When isoptin was given in a dose of 2.5 mg/kg/bw. to rats with 310 mg/kg/bw. methol, the decrease of the heart rate was much slower than before, for a period of 255 minutes, followed by a slight increase until the end of the recording. Isoptin counteracts the bradycardia - producing effect of methol in rats during the study time (6 hours), and the effect after this period of time requires further investigations.

Original languageEnglish
Pages (from-to)87-97
Number of pages11
JournalActa Physiologica Hungarica
Volume87
Issue number1
Publication statusPublished - 2000

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Verapamil
Bradycardia
Heart Rate
Urethane
Oral Administration
Wistar Rats
Electrocardiography

Keywords

  • Cardiac activity
  • Isoptin
  • Methol

ASJC Scopus subject areas

  • Physiology

Cite this

Use of isoptin for counteracting the effect of methol on cardiac activity in experimental animals. / Domahidi, Jánus; Péter, Katica; Farkas, J.

In: Acta Physiologica Hungarica, Vol. 87, No. 1, 2000, p. 87-97.

Research output: Contribution to journalArticle

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