Use of different cellulose derivatives for the preparation of tablets with a high active agent content

D. Deák, K. Pintye-Hódi, P. Szabó-Révész, P. Kása, I. Erös, Zs Muskó

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Metronidazole tablets were prepared and the morphological and powder rheological parameters of metronidazole were tested. It was concluded that the flow properties of the crystals were unsuitable, and wet granulation was therefore preferred as the tablet manufacturing method. Different cellulose derivatives (hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylhydroxy ethylcellulose) were chosen as binders. Granulation was performed with a fluid bed apparatus, and tableting with an eccentric tablet machine. The physical parameters of tablets and dissolution of the drug were tested. It was concluded that the best physical parameters and dissolution were achieved with tablets prepared using hydroxypropyl cellulose (Klucel LF) at 10 kN.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalS.T.P. Pharma Sciences
Volume9
Issue number6
Publication statusPublished - Nov 1 1999

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Keywords

  • Cellulose derivatives
  • Dissolution
  • Fluid bed granulation
  • Metronidazole
  • Morphology
  • Physical parameters
  • Powder rheology
  • Tableting

ASJC Scopus subject areas

  • Pharmaceutical Science

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