Use of Computed Tomography and Histopathologic Review for Lung Lesions Produced by the Interaction Between Mycoplasma hyopneumoniae and Fumonisin Mycotoxins in Pigs

R. Pósa, T. Magyar, S. D. Stoev, R. Glávits, T. Donkó, I. Repa, Melinda Kovács

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mycoplasma hyopneumoniae has a primary role in the porcine respiratory disease complex (PRDC). The objective of this study was to determine whether fumonisin mycotoxins influence the character and/or the severity of pathological processes induced in the lungs of pigs by Mycoplasma hyopneumoniae. Four groups of pigs (n = 7/group) were used, one fed 20 ppm fumonisin B1 (FB1) from 16 days of age (group F), one only infected with M. hyopneumoniae on study day 30 (group M), and a group fed FB1 and infected with M. hyopneumoniae (group MF), along with an untreated control group (group C). Computed tomography (CT) scans of infected pigs (M and MF) on study day 44 demonstrated lesions extending to the cranial and middle or in the cranial third of the caudal lobe of the lungs. The CT images obtained on study day 58 showed similar but milder lesions in 5 animals from group M, whereas lungs from 2 pigs in group MF appeared progressively worse. The evolution of average pulmonary density calculated from combined pixel frequency values, as measured by quantitative CT, was significantly influenced by the treatment and the age of the animals. The most characteristic histopathologic lesion in FB1-treated pigs was pulmonary edema, whereas the pathomorphological changes in Mycoplasma-infected pigs were consistent with catarrhal bronchointerstitial pneumonia. FB1 aggravated the progression of infection, as demonstrated by severe illness requiring euthanasia observed in 1 pig and evidence of progressive pathology in 2 pigs (group MF) between study days 44 and 58.

Original languageEnglish
Pages (from-to)971-979
Number of pages9
JournalVeterinary Pathology
Volume50
Issue number6
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Mycoplasma hyopneumoniae
Fumonisins
Mycotoxins
fumonisins
computed tomography
lesions (animal)
Swine
lungs
Tomography
Lung
swine
fumonisin B1
Swine Diseases
Bronchopneumonia
Euthanasia
Mycoplasma
bronchopneumonia
Pulmonary Edema
Pathologic Processes
animal age

Keywords

  • computed tomography
  • fumonisin B1
  • histopathology
  • Mycoplasma hyopneumoniae
  • pig

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

Cite this

Use of Computed Tomography and Histopathologic Review for Lung Lesions Produced by the Interaction Between Mycoplasma hyopneumoniae and Fumonisin Mycotoxins in Pigs. / Pósa, R.; Magyar, T.; Stoev, S. D.; Glávits, R.; Donkó, T.; Repa, I.; Kovács, Melinda.

In: Veterinary Pathology, Vol. 50, No. 6, 11.2013, p. 971-979.

Research output: Contribution to journalArticle

Pósa, R. ; Magyar, T. ; Stoev, S. D. ; Glávits, R. ; Donkó, T. ; Repa, I. ; Kovács, Melinda. / Use of Computed Tomography and Histopathologic Review for Lung Lesions Produced by the Interaction Between Mycoplasma hyopneumoniae and Fumonisin Mycotoxins in Pigs. In: Veterinary Pathology. 2013 ; Vol. 50, No. 6. pp. 971-979.
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