Use of cellulose‐based stationary phases for chiral separation in open tubular column chromatography

Z. Juvancz, K. Grolimund, E. Francotte

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Application of cellulose‐based chiral stationary phases was extended to open tubular columns. These chiral materials were mixed with achiral matrix stationary phases. Compromises were found among the polarity and the ratio of achiral matrix polymers against the content of the chiral cellulose derivative in order to optimize the resolution of the investigated racemates. In GC, the high efficiency feature of open tubular columns allows fast analysis, however, compounds which express strong H‐bond interaction with cellulose derivatives elute with a bad peak shape. The application of these stationary phases for open tubular SFC was more successful, because the solvation power of the mobile phase can compensate the strong interaction between the solute and the cellulose derivative. Immobilization of the stationary phases were achieved for SFC purposes. © 1992 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalChirality
Volume4
Issue number7
DOIs
Publication statusPublished - 1992

Keywords

  • GC
  • SFC
  • enantioselective stationary phases
  • mixed stationary phases
  • open tubular columns

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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