The authors report on a növel biodegradable long acting (4-6 weeks) bone graft containing antibiotics. The driig delivery system containing vancomycin was used in a rabbit osteomyelitis model in order to evaluate the antimicrobial efficacy of the antibiotic bone graft. 40 aduit New Zealand rabbits were used. The animals were randomized in three groups. In group I no osteomyelitis was induced, the drug delivery system was implanted in the rabbits' tibia to prove the biodegradability in non-infected tissues. In group II and III MRSA induced osteomyelitis was carried out. In group II autologeous cancellous bone and the drug delivery system with vancomycin was used. In group III plain cancellous bone was fiiled in. 6 weeks post op the animals were sacrificed, histological, laboratory and radiological evaluations were performed. The drug delivery system together with vancomycin was effective against MRSA induced osteomyelitis, and did not inhibit the osteointegration. The technology is a powerful tool to fight bone infection and it is biodegradable as well.
|Translated title of the contribution||Use of bone grafts impregnated with long acting antibiotic in rabbit osteomyelitis model. Second communication|
|Number of pages||6|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - Jul 1 2012|
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