Hosszú hatóanyag-leadású antibiotikus csontgraftok alkalmazása állatkísérletes osteomyelitis modellben

Másodközlés

Translated title of the contribution: Use of bone grafts impregnated with long acting antibiotic in rabbit osteomyelitis model. Second communication

Zahár Ákos, Kocsis György, Lengyel Béla, Puskás Gábor, Laki Mónika, Hajdú Mária, I. Antal

Research output: Contribution to journalArticle

Abstract

The authors report on a növel biodegradable long acting (4-6 weeks) bone graft containing antibiotics. The driig delivery system containing vancomycin was used in a rabbit osteomyelitis model in order to evaluate the antimicrobial efficacy of the antibiotic bone graft. 40 aduit New Zealand rabbits were used. The animals were randomized in three groups. In group I no osteomyelitis was induced, the drug delivery system was implanted in the rabbits' tibia to prove the biodegradability in non-infected tissues. In group II and III MRSA induced osteomyelitis was carried out. In group II autologeous cancellous bone and the drug delivery system with vancomycin was used. In group III plain cancellous bone was fiiled in. 6 weeks post op the animals were sacrificed, histological, laboratory and radiological evaluations were performed. The drug delivery system together with vancomycin was effective against MRSA induced osteomyelitis, and did not inhibit the osteointegration. The technology is a powerful tool to fight bone infection and it is biodegradable as well.

Original languageHungarian
Pages (from-to)417-422
Number of pages6
JournalMagyar Allatorvosok Lapja
Volume134
Issue number7
Publication statusPublished - Jul 2012

Fingerprint

osteomyelitis
Osteomyelitis
animal communication
drug delivery systems
Vancomycin
Drug Delivery Systems
antibiotics
rabbits
Communication
biodegradability
bones
vancomycin
Anti-Bacterial Agents
Rabbits
Transplants
Bone and Bones
Methicillin-Resistant Staphylococcus aureus
Tibia
tibia
Technology

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Hosszú hatóanyag-leadású antibiotikus csontgraftok alkalmazása állatkísérletes osteomyelitis modellben : Másodközlés. / Ákos, Zahár; György, Kocsis; Béla, Lengyel; Gábor, Puskás; Mónika, Laki; Mária, Hajdú; Antal, I.

In: Magyar Allatorvosok Lapja, Vol. 134, No. 7, 07.2012, p. 417-422.

Research output: Contribution to journalArticle

Ákos, Zahár ; György, Kocsis ; Béla, Lengyel ; Gábor, Puskás ; Mónika, Laki ; Mária, Hajdú ; Antal, I. / Hosszú hatóanyag-leadású antibiotikus csontgraftok alkalmazása állatkísérletes osteomyelitis modellben : Másodközlés. In: Magyar Allatorvosok Lapja. 2012 ; Vol. 134, No. 7. pp. 417-422.
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