Use of adult male bonnet monkeys (Macaca radiata) for testing the biological activity of gonadotropin releasing hormone and its analogues

A. J. Rao, G. Kéri, S. G. Kotagi, R. Chakraborti, B. Shanmugavelu, N. Ravindranath

Research output: Contribution to journalArticle

Abstract

The effect of injecting agonistic and antagonistic analogues of gonadotropin releasing hormone analogues on serum testosterone levels was checked in adult and immature male bonnet monkeys. Of the agonistic analogues Buserelin, Ovurelin and D-Phe6 Gln8 GnRH were found to be most potent in increasing serum testosterone levels in the adult male bonnet monkeys. While 27-month-old monkeys responded well to des Gly10 GnRH, only marginal response was observed in the case of 15-month-old monkeys. Studies carried out with Ovurelin indicated that it was not effective in causing desensitization in adult monkeys. The antagonistic analogue was effective in blocking nocturnal surge of serum testosterone. Based on these studies it is suggested the adult male bonnet monkeys can be effectively used for testing the activity of GnRH analogues.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalAndrologia
Volume23
Issue number1
Publication statusPublished - 1991

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Macaca radiata
Gonadotropin-Releasing Hormone
Haplorhini
Testosterone
Serum
Buserelin

ASJC Scopus subject areas

  • Endocrinology
  • Nephrology

Cite this

Rao, A. J., Kéri, G., Kotagi, S. G., Chakraborti, R., Shanmugavelu, B., & Ravindranath, N. (1991). Use of adult male bonnet monkeys (Macaca radiata) for testing the biological activity of gonadotropin releasing hormone and its analogues. Andrologia, 23(1), 79-83.

Use of adult male bonnet monkeys (Macaca radiata) for testing the biological activity of gonadotropin releasing hormone and its analogues. / Rao, A. J.; Kéri, G.; Kotagi, S. G.; Chakraborti, R.; Shanmugavelu, B.; Ravindranath, N.

In: Andrologia, Vol. 23, No. 1, 1991, p. 79-83.

Research output: Contribution to journalArticle

Rao, AJ, Kéri, G, Kotagi, SG, Chakraborti, R, Shanmugavelu, B & Ravindranath, N 1991, 'Use of adult male bonnet monkeys (Macaca radiata) for testing the biological activity of gonadotropin releasing hormone and its analogues', Andrologia, vol. 23, no. 1, pp. 79-83.
Rao, A. J. ; Kéri, G. ; Kotagi, S. G. ; Chakraborti, R. ; Shanmugavelu, B. ; Ravindranath, N. / Use of adult male bonnet monkeys (Macaca radiata) for testing the biological activity of gonadotropin releasing hormone and its analogues. In: Andrologia. 1991 ; Vol. 23, No. 1. pp. 79-83.
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