Use-dependent effects of amiodarone on V̇max in cardiac Purkinje and ventricular muscle fibers

Andras Varro, Yutaka Nakaya, Victor Elharrar, Borys Surawicz

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60 Citations (Scopus)


Superfusion with 5 μg/ml amiodarone for 3-4h induced use-dependent V̇max block in dog Purkinje and guinea pig ventricular muscle fibers. The recovery from block was exponential with τ of 289 ± 30 ms in Purkinje (n = 7)and 282 ± 47 ms in muscle (n = 6) fibers. The onset of frequency-dependent V̇max block was rapid, i.e. reached steady state after 4.2 ± 0.5 beats (n = 5). The combination of rapid interaction with sodium channel and the reported action potential lengthening make amiodarone unique among Class I antiarrhythmic drugs.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number3
Publication statusPublished - Jun 19 1985


  • Amiodarone
  • Dog Purkinje fibers
  • Guinea pig papillary muscle
  • Use-dependent V

ASJC Scopus subject areas

  • Pharmacology

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