Urinary prostaglandins in hyperglycaemic ketoacidosis of type I diabetes mellitus

Miklós Miltényi, T. Tulassay, A. Szabó, A. Körner, Hannsjörg W. Seyberth

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Urinary excretion of various renal prostaglandins was measured by radioimmunoassay and gas chromatography-mass spectrometry in children who had different degrees of metabolic control. Excretion in PGE2 in diabetic children was twice control values irrespective of the presence or absence of diabetic ketoacidosis (DKA). The urinary excretion of PGF was significantly increased in diabetic children with ketoacidosis, but not when diabetes was well controlled. The excretion of 13, 14 dihydro-15-keto PGE2, the major metabolite of circulating PGE2, was increased in all diabetic children, and was most elevated in ketoacidosis when it averaged 10 times basal excretion. Urinary excretion of PGI and of 6-keto-PGF, the metabolite of PGI2, was approximately doubled in DKA compared with values from healthy subjects. Excretion of PGE2 was twice control values in children with stable diatetes, whereas the equivalent value for TXB2, the metabolite of the active vasoconstrictor TXA2, was reduced by approximately 50%. We suggest that the increased excretion of prostacyclin metabolite may result from a protective biological action on the kidney opposing other vasoconstrictor hormone activity. PGE2 appears not to be involved in this process. The highly elevated excretion of PGE2 metabolite may represent an activation of systemic PGE metabolism during DKA.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalPediatric Nephrology
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 1990

Fingerprint

Ketosis
Type 1 Diabetes Mellitus
Dinoprostone
Prostaglandins
Diabetic Ketoacidosis
Epoprostenol
Vasoconstrictor Agents
Dinoprost
Prostaglandins E
Gas Chromatography-Mass Spectrometry
Radioimmunoassay
Healthy Volunteers
Hormones
Kidney

Keywords

  • Diabetes mellitus
  • Gas chromatography
  • Ketoacidosis
  • Mass spectrometry
  • Radioimmunoassay
  • Urinary prostaglandins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Urinary prostaglandins in hyperglycaemic ketoacidosis of type I diabetes mellitus. / Miltényi, Miklós; Tulassay, T.; Szabó, A.; Körner, A.; Seyberth, Hannsjörg W.

In: Pediatric Nephrology, Vol. 4, No. 1, 01.1990, p. 44-47.

Research output: Contribution to journalArticle

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