Urinary orosomucoid a potential marker of inflammation in Psoriasis

Péter Kustán, Tamás Kőszegi, Attila Miseta, Iván Péter, Zénó Ajtay, István Kiss, Balázs Németh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Psoriasis is one of the most common chronic, life-long dermatologic diseases, which has considerable negative effects on quality of life. Psoriasis is considered as a systemic inflammatory disease, thus acute phase proteins such as C-reactive protein (CRP) and orosomucoid (ORM) have been shown to play a role in its pathophysiology. This study was aimed to compare CRP, serum ORM (se-ORM) and urinary ORM (u-ORM) levels of psoriatic patients to healthy individuals. Methods: 87 psoriatic patients and 41 healthy individuals were enrolled. Simultaneously obtained venous blood and spot urine samples were analysed. High sensitivity CRP and se-ORM levels were determined by routine procedures on automated analyzers. Urinary ORM was measured by a novel automated turbidimetric assay. U-ORM was referred to urinary creatinine (u-ORM/u-CREAT, mg/mmol). Results: Significantly higher hsCRP (p<0.001) and u-ORM/u-CREAT (p=0.001) levels were found among psoriatic patients compared to controls. No significant differences were found between the groups regarding se-ORM levels. HsCRP, se-ORM and u-ORM/u-CREAT levels were significantly higher in patients with severe psoriasis than in mild and moderate cases (p<0.05). Conclusion: As a highly sensitive, easily available biomarker u-ORM shows itself capable of becoming a new inflammatory marker in psoriasis providing clinically useful information on disease severity.

Original languageEnglish
Pages (from-to)1113-1117
Number of pages5
JournalInternational Journal of Medical Sciences
Volume15
Issue number11
DOIs
Publication statusPublished - Jul 13 2018

Keywords

  • Biomarker
  • Inflammation
  • Orosomucoid
  • Psoriasis
  • Urine

ASJC Scopus subject areas

  • Medicine(all)

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