Urinary mineral concentrations in European pre-adolescent children and their association with calcaneal bone quantitative ultrasound measurements

IDEFICS Consortium

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Abstract

This study investigates differences and associations between urinary mineral concentrations and calcaneal bone measures assessed by quantitative ultrasonography (QUS) in 4322 children (3.1–11.9 years, 50.6% boys) from seven European countries. Urinary mineral concentrations and calcaneal QUS parameters differed significantly across countries. Clustering revealed a lower stiffness index (SI) in children with low and medium urinary mineral concentrations, and a higher SI in children with high urinary mineral concentrations. Urinary sodium (uNa) was positively correlated with urinary calcium (uCa), and was positively associated with broadband ultrasound attenuation and SI after adjustment for age, sex and fat-free mass. Urinary potassium (uK) was negatively correlated with uCa but positively associated with speed of sound after adjustment. No association was found between uCa and QUS parameters after adjustment, but when additionally adjusting for uNa, uCa was negatively associated with SI. Our findings suggest that urinary mineral concentrations are associated with calcaneal QUS parameters and may therefore implicate bone properties. These findings should be confirmed in longitudinal studies that include the food intake and repeated measurement of urinary mineral concentrations to better estimate usual intake and minimize bias.

Original languageEnglish
Article number471
JournalInternational Journal of Environmental Research and Public Health
Volume13
Issue number5
DOIs
Publication statusPublished - May 5 2016

Fingerprint

Minerals
Bone and Bones
Ultrasonography
Calcium
Sodium
Cluster Analysis
Longitudinal Studies
Potassium
Eating
Fats

Keywords

  • Calcaneal quantitative ultrasound
  • Calcium
  • Children
  • Magnesium
  • Phosphate
  • Potassium
  • Sodium

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

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title = "Urinary mineral concentrations in European pre-adolescent children and their association with calcaneal bone quantitative ultrasound measurements",
abstract = "This study investigates differences and associations between urinary mineral concentrations and calcaneal bone measures assessed by quantitative ultrasonography (QUS) in 4322 children (3.1–11.9 years, 50.6{\%} boys) from seven European countries. Urinary mineral concentrations and calcaneal QUS parameters differed significantly across countries. Clustering revealed a lower stiffness index (SI) in children with low and medium urinary mineral concentrations, and a higher SI in children with high urinary mineral concentrations. Urinary sodium (uNa) was positively correlated with urinary calcium (uCa), and was positively associated with broadband ultrasound attenuation and SI after adjustment for age, sex and fat-free mass. Urinary potassium (uK) was negatively correlated with uCa but positively associated with speed of sound after adjustment. No association was found between uCa and QUS parameters after adjustment, but when additionally adjusting for uNa, uCa was negatively associated with SI. Our findings suggest that urinary mineral concentrations are associated with calcaneal QUS parameters and may therefore implicate bone properties. These findings should be confirmed in longitudinal studies that include the food intake and repeated measurement of urinary mineral concentrations to better estimate usual intake and minimize bias.",
keywords = "Calcaneal quantitative ultrasound, Calcium, Children, Magnesium, Phosphate, Potassium, Sodium",
author = "{IDEFICS Consortium} and {Van Den Bussche}, Karen and Diana Herrmann and {De Henauw}, Stefaan and Kourides, {Yiannis A.} and Fabio Lauria and Staffan Marild and D. Moln{\'a}r and Moreno, {Luis A.} and Toomas Veidebaum and Wolfgang Ahrens and Isabelle Sioen",
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T1 - Urinary mineral concentrations in European pre-adolescent children and their association with calcaneal bone quantitative ultrasound measurements

AU - IDEFICS Consortium

AU - Van Den Bussche, Karen

AU - Herrmann, Diana

AU - De Henauw, Stefaan

AU - Kourides, Yiannis A.

AU - Lauria, Fabio

AU - Marild, Staffan

AU - Molnár, D.

AU - Moreno, Luis A.

AU - Veidebaum, Toomas

AU - Ahrens, Wolfgang

AU - Sioen, Isabelle

PY - 2016/5/5

Y1 - 2016/5/5

N2 - This study investigates differences and associations between urinary mineral concentrations and calcaneal bone measures assessed by quantitative ultrasonography (QUS) in 4322 children (3.1–11.9 years, 50.6% boys) from seven European countries. Urinary mineral concentrations and calcaneal QUS parameters differed significantly across countries. Clustering revealed a lower stiffness index (SI) in children with low and medium urinary mineral concentrations, and a higher SI in children with high urinary mineral concentrations. Urinary sodium (uNa) was positively correlated with urinary calcium (uCa), and was positively associated with broadband ultrasound attenuation and SI after adjustment for age, sex and fat-free mass. Urinary potassium (uK) was negatively correlated with uCa but positively associated with speed of sound after adjustment. No association was found between uCa and QUS parameters after adjustment, but when additionally adjusting for uNa, uCa was negatively associated with SI. Our findings suggest that urinary mineral concentrations are associated with calcaneal QUS parameters and may therefore implicate bone properties. These findings should be confirmed in longitudinal studies that include the food intake and repeated measurement of urinary mineral concentrations to better estimate usual intake and minimize bias.

AB - This study investigates differences and associations between urinary mineral concentrations and calcaneal bone measures assessed by quantitative ultrasonography (QUS) in 4322 children (3.1–11.9 years, 50.6% boys) from seven European countries. Urinary mineral concentrations and calcaneal QUS parameters differed significantly across countries. Clustering revealed a lower stiffness index (SI) in children with low and medium urinary mineral concentrations, and a higher SI in children with high urinary mineral concentrations. Urinary sodium (uNa) was positively correlated with urinary calcium (uCa), and was positively associated with broadband ultrasound attenuation and SI after adjustment for age, sex and fat-free mass. Urinary potassium (uK) was negatively correlated with uCa but positively associated with speed of sound after adjustment. No association was found between uCa and QUS parameters after adjustment, but when additionally adjusting for uNa, uCa was negatively associated with SI. Our findings suggest that urinary mineral concentrations are associated with calcaneal QUS parameters and may therefore implicate bone properties. These findings should be confirmed in longitudinal studies that include the food intake and repeated measurement of urinary mineral concentrations to better estimate usual intake and minimize bias.

KW - Calcaneal quantitative ultrasound

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KW - Magnesium

KW - Phosphate

KW - Potassium

KW - Sodium

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