Urinary glycosaminoglycan excretion in healthy and stone-forming children

Ferenc Harangi, Zsuzsanna Györke, B. Melegh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Both in vivo and in vitro studies suggest that macromolecules excreted in the urine, e.g. glycosaminoglycans (GAGs) may be inhibitors of kidney stone formation. We evaluated urinary GAG excretion in 22 children with calcium oxalate stones [8 with absorptive hypercalciuria, 6 with renal hypercalciuria (RH), 8 with normocalciuria], and in 20 age-matched controls. There was no significant difference between the two groups in the total urinary GAG level. In terms of the various GAG fraction, patients with RH excreted considerably less keratan sulphate and considerably more dermatan sulphate than the other patients and healthy controls. There was no difference between the two groups in condroitin sulphate, heparan sulphate and hyaluronic acid excretion. We conclude that there is no significant correlation between the formation of calcium oxalate stones and urinary GAG excretion.

Original languageEnglish
Pages (from-to)555-558
Number of pages4
JournalPediatric Nephrology
Volume10
Issue number5
DOIs
Publication statusPublished - Oct 1996

Fingerprint

Glycosaminoglycans
Hypercalciuria
Calcium Oxalate
Keratan Sulfate
Kidney
Dermatan Sulfate
Urinary Calculi
Kidney Calculi
Heparitin Sulfate
Hyaluronic Acid
Sulfates
Urine

Keywords

  • Paediatric urolithiasis
  • Urinary glycosaminoglycan excretion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Urinary glycosaminoglycan excretion in healthy and stone-forming children. / Harangi, Ferenc; Györke, Zsuzsanna; Melegh, B.

In: Pediatric Nephrology, Vol. 10, No. 5, 10.1996, p. 555-558.

Research output: Contribution to journalArticle

Harangi, Ferenc ; Györke, Zsuzsanna ; Melegh, B. / Urinary glycosaminoglycan excretion in healthy and stone-forming children. In: Pediatric Nephrology. 1996 ; Vol. 10, No. 5. pp. 555-558.
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