Urinary excretion of prostaglandin E and F2α in healthy newborn infants and in infants with hyaline membrane disease

I. F. Csaba, E. Sulyok, T. Ertl

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Abstract

Urinary PGE and PGF(2α) excretion was estimated in 11 healthy full-term (mean birth weight, 3327 g; mean gestational age, 39.2 weeks), 15 healthy preterm (mean birth weight, 1722 g; mean gestational age, 32.1 weeks) and in 9 preterm infants suffering from hyaline membrane disease (HMD) (mean birth weight, 1454 g; mean gestational age, 31 weeks). Measurements were carried out on the 1st, 3rd and 5th days of life by radioimmunoassay, using Clinical Assays Inc. RIA kits. Urinary PGE excretion on the first day of life was 3.76 ± 0.41 ng/day, 2.43 ± 0.65 ng/day and 1.19 ± 0.27 ng/day for healthy full-term, healthy premature and premature infants with HMD, respectively. The differences were significant at the level of p < 0.05. With advancing postnatal age urinary PGE excretion markedly increased in each group (p < 0.05). Urinary PGF(2α) excretion on the first day was 10.8 ± 2.0 ng/day in full-term, 6.6 ± 2.2 ng/day in healthy premature, and 4.35 ± 1.9 ng/day in premature infants with HMD. Then an inconsistent rise could be observed without statistically significant difference between the individual groups of the same postnatal age. The decreased renal PGE production is suggested to be involved in the pathomechanism of HMD.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalActa paediatrica Academiae Scientiarum Hungaricae
Volume20
Issue number2-3
Publication statusPublished - Dec 1 1979

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ASJC Scopus subject areas

  • Medicine(all)

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