Urinary excretion of individual 17-ketosteroids by normal children

A. Kádár, T. Fehér, O. Koref

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The individual 17-KS in the urine of 52 normal children of different age and sex have been determined by the authors by means of the paper chromatographic method. Of the six fractions that can be separated by this method, hardly any quantitative change occurs with increasing age in the elimination of the 1 l-oxy-17-KS. On the other hand the quantity of 11-desoxy-17-KS rises significantly with age. Of the ratios computed from the various groups of the 17-KS fractions which reflect the function of the adrenal cortex, the 11-oxy- 17-KS/i 1-desoxy-17-KS ratio is very high in infancy and decreases to the adult value at the advent of puberty. The E/A value is usually higher in children than in adults, and the high E/A value measured immediately before puberty seems to indicate an increased production of pre-androgens in the adrenal cortex. The total amount of 17-KS and of 17-OH determined simultaneously reaches the values of adults after a gradual increase beginning in infancy. For their technical assistance we are indebted to Miss Kornelia Adok and Miss Mdria Kazik.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalArchives of Disease in Childhood
Volume39
Issue number205
DOIs
Publication statusPublished - 1964

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17-Ketosteroids
Adrenal Cortex
Puberty
Androgens
Urine

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

Cite this

Urinary excretion of individual 17-ketosteroids by normal children. / Kádár, A.; Fehér, T.; Koref, O.

In: Archives of Disease in Childhood, Vol. 39, No. 205, 1964, p. 257-260.

Research output: Contribution to journalArticle

Kádár, A. ; Fehér, T. ; Koref, O. / Urinary excretion of individual 17-ketosteroids by normal children. In: Archives of Disease in Childhood. 1964 ; Vol. 39, No. 205. pp. 257-260.
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