Urinary excretion of endogenous ouabain-like substance is reduced in NaCl supplemented premature infants

S. Worgall, W. Rascher, G. Gyódi, Z. Nyul, Z. Baranyai, E. Sulyok

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Ouabain or an isomer has been identified as endogenous ouabain-like substance (EOLS). The role of EOLS in the adaptation of premature infants to alterations of sodium balance was investigated by measuring urinary ouabain excretion serially in 9 low birth weight premature infants with (group S, mean birth weight 1578 g, mean gestational age 30.4 weeks) and without (group NS, mean birth weight 1537 g, mean gestational age 30.8 weeks) NaCl supplementation. The study was performed on the 7th day and weekly thereafter until the 5th week of life. NaCl supplementation was given in a dose of 3-5 and 1.5-2.5 mmol/kg/day at the postnatal ages of 8-21 and 22-35 days, respectively. Prior to NaCl supplementation, urinary ouabain excretion was similar in the two groups (146.2 ± 16.8 pg/kg/h in group S versus 180.0 ± 9.6 pg/kg/h in group NS) and remained at about the same level throughout the study when supplemental NaCl was provided. In infants of group NS, urinary ouabain excretion increased significantly by the 3rd week (p <0.01) and no consistent change occurred later on. As a result, the differences in urinary ouabain excretion between the two groups proved to be significant during weeks 2-5 (p <0.001). Essentially the same pattern of ouabain excretion was seen when it was expressed in terms of pg/mg creatinine. In infants receiving high sodium diet there was a significant positive correlation between urinary sodium and ouabain excretion. It is concluded that premature infants receiving low sodium intake have elevated EOLS excretion by the 3rd week of life. Although the relationship between ouabain and sodium excretion in supplemented premature infants suggests some physiological significance for sodium excretion, ouabain does not appear to be regulated by extracellular volume.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalBiology of the Neonate
Volume72
Issue number6
Publication statusPublished - Dec 1997

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Ouabain
Premature Infants
Sodium
Birth Weight
Gestational Age
Low Birth Weight Infant
Creatinine
Diet

Keywords

  • Endogenous ouabain
  • Premature infants
  • Sodium balance

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Urinary excretion of endogenous ouabain-like substance is reduced in NaCl supplemented premature infants. / Worgall, S.; Rascher, W.; Gyódi, G.; Nyul, Z.; Baranyai, Z.; Sulyok, E.

In: Biology of the Neonate, Vol. 72, No. 6, 12.1997, p. 337-344.

Research output: Contribution to journalArticle

Worgall, S, Rascher, W, Gyódi, G, Nyul, Z, Baranyai, Z & Sulyok, E 1997, 'Urinary excretion of endogenous ouabain-like substance is reduced in NaCl supplemented premature infants', Biology of the Neonate, vol. 72, no. 6, pp. 337-344.
Worgall, S. ; Rascher, W. ; Gyódi, G. ; Nyul, Z. ; Baranyai, Z. ; Sulyok, E. / Urinary excretion of endogenous ouabain-like substance is reduced in NaCl supplemented premature infants. In: Biology of the Neonate. 1997 ; Vol. 72, No. 6. pp. 337-344.
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