Urinary cytokine response to asymptomatic bacteriuria in type 1 diabetic children and young adults

Barnabás Rózsai, Éva Lányi, T. Berki, G. Soltész

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It has been reported that urinary interleukin-6 (IL-6) and IL-8 levels are decreased in adult diabetic women with asymptomatic bacteriuria (ASB) when compared with non-diabetic women with ASB. Such impaired cytokine excretion might play a role in the higher prevalence of ASB among diabetic subjects. The aim of this study was to examine the urinary IL profile in children and young adults with type 1 diabetes mellitus (T1DM) with and without ASB. Midstream clean voiding urine samples were collected and cultured from 133 patients with T1DM (age: 15.6 ± 5.7 yr) and 178 controls (14.1 ± 4.7 yr) for two consecutive days. ASB was diagnosed in the case of ≥105 bacteria/mL. The urinary IL-6 and IL-8 concentrations were determined, and the presence of leukocyturia was also recorded. The prevalence of ASB was 16.5% in diabetic subjects and 2.8% in controls (p = 0.001). There was no difference between the diabetic and the control groups in the prevalence of 'IL-6-uria' (21.9 vs. 18.0%; p = 0.41), but IL-8 was more frequently detectable in the diabetic group (47.4 vs. 27.5%; p= 0.001). In individuals with ASB, the IL-8 level was similar in the diabetic (median: 70.0 pg/mg creatinine) and control group (42.3 pg/mg creatinine; p = 0.8). Indeed, the IL-8 levels were higher in diabetic subjects with ASB as compared with those without it (70.0 vs.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalPediatric Diabetes
Volume7
Issue number3
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Bacteriuria
Young Adult
Cytokines
Interleukin-8
Interleukin-6
Type 1 Diabetes Mellitus
Creatinine
Control Groups
Urine
Bacteria

Keywords

  • Asymptomatic bacteriuria
  • Interleukin-6
  • Interleukin-8
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Urinary cytokine response to asymptomatic bacteriuria in type 1 diabetic children and young adults. / Rózsai, Barnabás; Lányi, Éva; Berki, T.; Soltész, G.

In: Pediatric Diabetes, Vol. 7, No. 3, 06.2006, p. 153-158.

Research output: Contribution to journalArticle

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