Urinary and serum mutagenicity studies with rats bearing experimental tumours

C. S. Varga, Z. Pocsai, P. Kertai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Urine and serum samples of rats bearing three different experimental tumours (hepatocellular carcinoma, myelomonocytic leukemia and mesoblastic nephroma) were investigated for mutagenicity with the Ames Salmonella test. Enhancement of mutagenic activity in TA98 and TA100 was observed only in the case of urine samples obtained from animals bearing nephromas. Mutagenicity increased with increasing time after implantation of tumours. There was no coincidence between urinary and serum mutagenicity under the experimental conditions employed. Further studies are needed to determine the origins, and chemical and genotoxic characteristics of urinary mutagens. In addition, the question as to whether any mutagenic substances can be detected in fractions of plasma/serum should also be experimentally addressed.

Original languageEnglish
Pages (from-to)43-45
Number of pages3
JournalMutagenesis
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 1995

Fingerprint

Bearings (structural)
Rats
Tumors
Tumor
Mutagens
Salmonella
Implantation
Leukemia
Mesoblastic Nephroma
Coincidence
Serum
Urine
Animals
Neoplasms
Plasma
Enhancement
Plasmas
Hepatocellular Carcinoma
Rat

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Urinary and serum mutagenicity studies with rats bearing experimental tumours. / Varga, C. S.; Pocsai, Z.; Kertai, P.

In: Mutagenesis, Vol. 10, No. 1, 01.1995, p. 43-45.

Research output: Contribution to journalArticle

Varga, C. S. ; Pocsai, Z. ; Kertai, P. / Urinary and serum mutagenicity studies with rats bearing experimental tumours. In: Mutagenesis. 1995 ; Vol. 10, No. 1. pp. 43-45.
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