Upregulation of cyp2e1 and cyp3a activities in histamine-deficient histidine decarboxylase gene targeted mice

Viola Tamási, A. Kristóf Fülöp, Krisztina Hegyi, Katalin Monostory, András Falus

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Histamine is a biogenic amine with multiple physiological functions. Its importance in allergic inflammation is well characterized; moreover, it plays a role in the regulation of gastric acid production, various hypothalamic functions, such as food uptake, and enhancing TH2 balance during immune responses. Using histidine decarboxylase gene targeted (HDC-/-) BALB/c mice, we studied the effect of the absence of histamine on four cytochrome P450 enzyme activities. Their selective substrates were measured: ethoxyresorufin O-dealkylase activity of CYP1A, pentoxyresorufin O-dealkylase activity of CYP2B, chlorzoxazone 6-hydroxylase activity of CYP2E1 and ethylmorphine N-demethylase activity of CYP3A. The results indicate a significant elevation of CYP2E1 and CYP3A activities, however, no change in CYP1A and CYP2B activities was seen in HDC targeted mice compared to wild type controls with identical genetic backgrounds.

Original languageEnglish
Pages (from-to)1011-1015
Number of pages5
JournalCell biology international
Volume27
Issue number12
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • Cytochrome P450
  • Histamine

ASJC Scopus subject areas

  • Cell Biology

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