Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics

Erzsébet Kövesdi, János Lückl, Péter Bukovics, O. Farkas, J. Pál, Endre Czeiter, Dóra Szellár, T. Dóczi, S. Komoly, A. Büki

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Purpose: This review summarizes protein biomarkers in mild and severe traumatic brain injury in adults and children and presents a strategy for conducting rationally designed clinical studies on biomarkers in head trauma. Methods: We performed an electronic search of the National Library of Medicine's MEDLINE and Biomedical Library of University of Pennsylvania database in March 2008 using a search heading of traumatic head injury and protein biomarkers. The search was focused especially on protein degradation products (spectrin breakdown product, c-tau, amyloid-β1-42) in the last 10 years, but recent data on "classical" markers (S-100B, neuron-specific enolase, etc.) were also examined. Results: We identified 85 articles focusing on clinical use of biomarkers; 58 articles were prospective cohort studies with injury and/or outcome assessment. Conclusions: We conclude that only S-100B in severe traumatic brain injury has consistently demonstrated the ability to predict injury and outcome in adults. The number of studies with protein degradation products is insufficient especially in the pediatric care. Cohort studies with well-defined end points and further neuroproteomic search for biomarkers in mild injury should be triggered. After critically reviewing the study designs, we found that large homogenous patient populations, consistent injury, and outcome measures prospectively determined cutoff values, and a combined use of different predictors should be considered in future studies.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalActa Neurochirurgica
Volume152
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Biomarkers
Pediatrics
Wounds and Injuries
Proteins
Craniocerebral Trauma
Proteolysis
Cohort Studies
Brain Concussion
Outcome Assessment (Health Care)
National Library of Medicine (U.S.)
Spectrin
Phosphopyruvate Hydratase
Amyloid
MEDLINE
Libraries
Traumatic Brain Injury
Databases
Prospective Studies
Population

Keywords

  • Biomarkers
  • Mild
  • Outcome
  • Pediatric
  • Review
  • Severe
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics. / Kövesdi, Erzsébet; Lückl, János; Bukovics, Péter; Farkas, O.; Pál, J.; Czeiter, Endre; Szellár, Dóra; Dóczi, T.; Komoly, S.; Büki, A.

In: Acta Neurochirurgica, Vol. 152, No. 1, 01.2010, p. 1-17.

Research output: Contribution to journalArticle

Kövesdi, Erzsébet ; Lückl, János ; Bukovics, Péter ; Farkas, O. ; Pál, J. ; Czeiter, Endre ; Szellár, Dóra ; Dóczi, T. ; Komoly, S. ; Büki, A. / Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics. In: Acta Neurochirurgica. 2010 ; Vol. 152, No. 1. pp. 1-17.
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