Update on microbe-induced epigenetic changes: Bacterial effectors and viral oncoproteins as epigenetic dysregulators

Hans Helmut Niller, Ferenc Banati, Katalin Nagy, Krisztina Buzas, Janos Minarovits

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Pathoepigenetics is a new discipline describing how disturbances in epigenetic regulation alter the epigenotype and gene-expression pattern of human, animal or plant cells. Such 'epigenetic reprogramming' may play an important role in the initiation and progression of a wide variety of diseases. Infectious diseases also belong to this category: recent data demonstrated that microbial pathogens, including bacteria and viruses, are capable of dysregulating the epigenetic machinery of their host cell. The resulting heritable changes in host cell gene expression may favor the colonization, growth or spread of infectious pathogens. It may also facilitate the establishment of latency and malignant cell transformation. In this article, we review how bacterial epigenetic effectors and inflammatory processes elicited by bacteria alter the host cell epigenotype, and describe how oncoproteins encoded by human tumor viruses act as epigenetic dysregulators to alter the phenotype and behavior of host cells.

Original languageEnglish
Pages (from-to)1111-1126
Number of pages16
JournalFuture Virology
Volume8
Issue number11
DOIs
Publication statusPublished - Nov 1 2013

Keywords

  • DNA methylation
  • Polycomb and Trithorax complexes
  • epigenetic regulation
  • histone modification
  • oncovirus
  • pathoepigenetics
  • pioneer transcription factor
  • tumorigenesis

ASJC Scopus subject areas

  • Virology

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