Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging

Heike S. Mader, P. Kele, Sayed M. Saleh, Otto S. Wolfbeis

Research output: Contribution to journalArticle

359 Citations (Scopus)

Abstract

Upconverting luminescent nanoparticles (UCNPs) display the unique property of emitting visible light following photoexcitation with near-infrared laser light. This results in features such as virtually zero autofluorescence of (biological) matter and easy separation of the emission peaks from stray light. Other features include rather narrow emission bands, very high chemical stability, the lack of bleaching, and the absence of blinking effects. This article reviews the work performed in the past few years with UCNPs in terms of surface modifications, bioconjugation, and optical (cellular) imaging.

Original languageEnglish
Pages (from-to)582-596
Number of pages15
JournalCurrent Opinion in Chemical Biology
Volume14
Issue number5
DOIs
Publication statusPublished - Oct 2010

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Nanoparticles
Stray light
Light
Infrared lasers
Photoexcitation
Chemical stability
Bleaching
Surface treatment
Blinking
Optical Imaging
Imaging techniques
Lasers

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry

Cite this

Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging. / Mader, Heike S.; Kele, P.; Saleh, Sayed M.; Wolfbeis, Otto S.

In: Current Opinion in Chemical Biology, Vol. 14, No. 5, 10.2010, p. 582-596.

Research output: Contribution to journalArticle

Mader, Heike S. ; Kele, P. ; Saleh, Sayed M. ; Wolfbeis, Otto S. / Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging. In: Current Opinion in Chemical Biology. 2010 ; Vol. 14, No. 5. pp. 582-596.
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