Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus.

Zsolt Bagi, N. Erdei, Z. Papp, I. Édes, Akos Koller

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Diabetes mellitus is associated with disturbed regulation in the microcirculation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying molecular mechanisms has not yet been fully elucidated. It is known that cyclooxygenase-2 (COX-2) plays a key role in prostaglandin biosynthesis during the development of inflammation. Recent studies revealed that in diabetes increased synthesis of various prostanoids, via up-regulation of COX-2, interferes with the regulation of vasomotor function. In this review, we will summarize the current findings regarding the role of COX-2, and COX-2-derived prostanoids in the regulation of vascular tone, as well as the possible underlying mechanisms leading to COX-2 activation in diabetes mellitus.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalPharmacological Reports
Volume58 Suppl
Publication statusPublished - 2006

Fingerprint

Cyclooxygenase 2
Blood Vessels
Diabetes Mellitus
Up-Regulation
Prostaglandins
Inflammation
Diabetes Complications
Microcirculation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus. / Bagi, Zsolt; Erdei, N.; Papp, Z.; Édes, I.; Koller, Akos.

In: Pharmacological Reports, Vol. 58 Suppl, 2006, p. 52-56.

Research output: Contribution to journalArticle

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