Unusual tigliane diterpenes from euphorbia grandicornis

Peter Forgo, Dóra Rédei, Zsanett Hajdu, Pál Szabó, László Szabó, Judit Hohmann

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Phytochemical study of the aerial parts of Euphorbia grandicornis led to the isolation of two new tigliane diterpenes, 16-angeloyloxy-13α- isobutanoyloxy-4β,9α,20-trihydroxytiglia-1,5-diene-3,7-dione (1) and 16-angeloyloxy-13α-isobutanoyloxy-4β,9α,7β- trihydroxytiglia-1,5-dien-3-one (2). The structures and relative configuration of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments (1H NMR, JMOD, 1H-1H COSY, NOESY, HSQC, and HMBC), mass spectrometry, and comparison with literature data. The biogenesis of 1 and 2 with respect to the unusual 5-en-7-one and 5-en-7-ol moieties is also discussed.

Original languageEnglish
Pages (from-to)639-643
Number of pages5
JournalJournal of Natural Products
Volume74
Issue number4
DOIs
Publication statusPublished - Apr 25 2011

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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