Unusual phenomena during the resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ): Thermodynamic-kinetic control

J. Bálint, G. Egri, Violetta Kiss, Antal Gajáry, Z. Juvancz, E. Fogassy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved in several different solvents by tartaric acid derivatives as the most common acidic resolving agents available in industrial quantities. Strong reaction kinetics and solvent dependence were observed, curiously without solvation. In possession of these findings, an economic resolution process is proposed, which is completed by the incorporation of a racemization step.

Original languageEnglish
Pages (from-to)3435-3439
Number of pages5
JournalTetrahedron Asymmetry
Volume12
Issue number24
DOIs
Publication statusPublished - Jan 21 2002

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Thermodynamics
thermodynamics
Kinetics
Solvation
kinetics
Reaction kinetics
solvation
economics
reaction kinetics
Economics
Derivatives
acids
Acids
6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
tartaric acid

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Unusual phenomena during the resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) : Thermodynamic-kinetic control. / Bálint, J.; Egri, G.; Kiss, Violetta; Gajáry, Antal; Juvancz, Z.; Fogassy, E.

In: Tetrahedron Asymmetry, Vol. 12, No. 24, 21.01.2002, p. 3435-3439.

Research output: Contribution to journalArticle

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