TY - JOUR
T1 - Unusual phenomena during the resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ)
T2 - Thermodynamic-kinetic control
AU - Bálint, József
AU - Egri, Gabriella
AU - Kiss, Violetta
AU - Gajáry, Antal
AU - Juvancz, Zoltán
AU - Fogassy, Elemér
PY - 2002/1/21
Y1 - 2002/1/21
N2 - 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved in several different solvents by tartaric acid derivatives as the most common acidic resolving agents available in industrial quantities. Strong reaction kinetics and solvent dependence were observed, curiously without solvation. In possession of these findings, an economic resolution process is proposed, which is completed by the incorporation of a racemization step.
AB - 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved in several different solvents by tartaric acid derivatives as the most common acidic resolving agents available in industrial quantities. Strong reaction kinetics and solvent dependence were observed, curiously without solvation. In possession of these findings, an economic resolution process is proposed, which is completed by the incorporation of a racemization step.
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U2 - 10.1016/S0957-4166(02)00021-6
DO - 10.1016/S0957-4166(02)00021-6
M3 - Article
AN - SCOPUS:0037148450
VL - 12
SP - 3435
EP - 3439
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
SN - 0957-4166
IS - 24
ER -