Abstract
6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved in several different solvents by tartaric acid derivatives as the most common acidic resolving agents available in industrial quantities. Strong reaction kinetics and solvent dependence were observed, curiously without solvation. In possession of these findings, an economic resolution process is proposed, which is completed by the incorporation of a racemization step.
| Original language | English |
|---|---|
| Pages (from-to) | 3435-3439 |
| Number of pages | 5 |
| Journal | Tetrahedron Asymmetry |
| Volume | 12 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - Jan 21 2002 |
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ASJC Scopus subject areas
- Inorganic Chemistry
- Organic Chemistry
- Materials Chemistry
- Drug Discovery
Cite this
Unusual phenomena during the resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) : Thermodynamic-kinetic control. / Bálint, J.; Egri, G.; Kiss, Violetta; Gajáry, Antal; Juvancz, Z.; Fogassy, E.
In: Tetrahedron Asymmetry, Vol. 12, No. 24, 21.01.2002, p. 3435-3439.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unusual phenomena during the resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ)
T2 - Thermodynamic-kinetic control
AU - Bálint, J.
AU - Egri, G.
AU - Kiss, Violetta
AU - Gajáry, Antal
AU - Juvancz, Z.
AU - Fogassy, E.
PY - 2002/1/21
Y1 - 2002/1/21
N2 - 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved in several different solvents by tartaric acid derivatives as the most common acidic resolving agents available in industrial quantities. Strong reaction kinetics and solvent dependence were observed, curiously without solvation. In possession of these findings, an economic resolution process is proposed, which is completed by the incorporation of a racemization step.
AB - 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved in several different solvents by tartaric acid derivatives as the most common acidic resolving agents available in industrial quantities. Strong reaction kinetics and solvent dependence were observed, curiously without solvation. In possession of these findings, an economic resolution process is proposed, which is completed by the incorporation of a racemization step.
UR - http://www.scopus.com/inward/record.url?scp=0037148450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037148450&partnerID=8YFLogxK
U2 - 10.1016/S0957-4166(02)00021-6
DO - 10.1016/S0957-4166(02)00021-6
M3 - Article
AN - SCOPUS:0037148450
VL - 12
SP - 3435
EP - 3439
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
SN - 0957-4166
IS - 24
ER -