A D-fruktóz szokatlan viselkedése dimetilón(IV)2+ kation jelenlétében: az alkoholos hidroxilcsoport fémion által indukált deprotonálódása vizes közegben, alacsony pH-n.

Translated title of the contribution: Unusual coordination behavior of D-fructose towards dimethyltin(IV)2+: metal-promoted deprotonation of alcoholic hydroxyl groups in aqueous solutions at low pH

L. Nagy, N. Buzás, J. H. Barátné, T. Gajda, E. Kuzmann, A. Vértes, K. Burger

Research output: Contribution to journalArticle

Abstract

To study the effect of the conformation of sugar hydroxy groups on metal complexation processes, complex formation of eight saccharides (D-fructose, L-sorbose, L-arabinose, D-arabinose, D-glucose, D-sorbitol, 2-deoxy-D-glucose and D-saccharose) with dimethyltin(IV)2+ cations was investigated in aqueous solution by potentiometric equilibrium measurements, 13C NMR, polarimetric and Mössbauer spectroscopic methods. The experimental results proved that deprotonation of D-fructose and L-sorbose is caused by the coordination of dimethyltin(IV)2+ in the unusual low pH interval 4-6 in contrast to the other saccharides deprotonated in analogous way at pH > 8. Increasing the pH of the solution resulted in the formation of further complexes. Stability and composition of the species was determined by potentiometric studies. 13C NMR measurements led to the assignment of the sugar OH groups participating in the processes. Mössbauer investigations in the quick-frozen solutions permitted the determination of the stereochemistry of tin(IV) in the complexes.

Original languageHungarian
Pages (from-to)9-19
Number of pages11
JournalActa Pharmaceutica Hungarica
Volume69
Issue number1
Publication statusPublished - Jan 1999

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Fructose
Sorbose
Hydroxyl Radical
Arabinose
Metals
Sorbitol
Tin
Deoxyglucose
Sucrose
Cations
Glucose
dimethyltin
Carbon-13 Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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title = "A D-frukt{\'o}z szokatlan viselked{\'e}se dimetil{\'o}n(IV)2+ kation jelenl{\'e}t{\'e}ben: az alkoholos hidroxilcsoport f{\'e}mion {\'a}ltal induk{\'a}lt deproton{\'a}l{\'o}d{\'a}sa vizes k{\"o}zegben, alacsony pH-n.",
abstract = "To study the effect of the conformation of sugar hydroxy groups on metal complexation processes, complex formation of eight saccharides (D-fructose, L-sorbose, L-arabinose, D-arabinose, D-glucose, D-sorbitol, 2-deoxy-D-glucose and D-saccharose) with dimethyltin(IV)2+ cations was investigated in aqueous solution by potentiometric equilibrium measurements, 13C NMR, polarimetric and M{\"o}ssbauer spectroscopic methods. The experimental results proved that deprotonation of D-fructose and L-sorbose is caused by the coordination of dimethyltin(IV)2+ in the unusual low pH interval 4-6 in contrast to the other saccharides deprotonated in analogous way at pH > 8. Increasing the pH of the solution resulted in the formation of further complexes. Stability and composition of the species was determined by potentiometric studies. 13C NMR measurements led to the assignment of the sugar OH groups participating in the processes. M{\"o}ssbauer investigations in the quick-frozen solutions permitted the determination of the stereochemistry of tin(IV) in the complexes.",
author = "L. Nagy and N. Buz{\'a}s and Bar{\'a}tn{\'e}, {J. H.} and T. Gajda and E. Kuzmann and A. V{\'e}rtes and K. Burger",
year = "1999",
month = "1",
language = "Hungarian",
volume = "69",
pages = "9--19",
journal = "Acta Pharmaceutica Hungarica",
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TY - JOUR

T1 - A D-fruktóz szokatlan viselkedése dimetilón(IV)2+ kation jelenlétében

T2 - az alkoholos hidroxilcsoport fémion által indukált deprotonálódása vizes közegben, alacsony pH-n.

AU - Nagy, L.

AU - Buzás, N.

AU - Barátné, J. H.

AU - Gajda, T.

AU - Kuzmann, E.

AU - Vértes, A.

AU - Burger, K.

PY - 1999/1

Y1 - 1999/1

N2 - To study the effect of the conformation of sugar hydroxy groups on metal complexation processes, complex formation of eight saccharides (D-fructose, L-sorbose, L-arabinose, D-arabinose, D-glucose, D-sorbitol, 2-deoxy-D-glucose and D-saccharose) with dimethyltin(IV)2+ cations was investigated in aqueous solution by potentiometric equilibrium measurements, 13C NMR, polarimetric and Mössbauer spectroscopic methods. The experimental results proved that deprotonation of D-fructose and L-sorbose is caused by the coordination of dimethyltin(IV)2+ in the unusual low pH interval 4-6 in contrast to the other saccharides deprotonated in analogous way at pH > 8. Increasing the pH of the solution resulted in the formation of further complexes. Stability and composition of the species was determined by potentiometric studies. 13C NMR measurements led to the assignment of the sugar OH groups participating in the processes. Mössbauer investigations in the quick-frozen solutions permitted the determination of the stereochemistry of tin(IV) in the complexes.

AB - To study the effect of the conformation of sugar hydroxy groups on metal complexation processes, complex formation of eight saccharides (D-fructose, L-sorbose, L-arabinose, D-arabinose, D-glucose, D-sorbitol, 2-deoxy-D-glucose and D-saccharose) with dimethyltin(IV)2+ cations was investigated in aqueous solution by potentiometric equilibrium measurements, 13C NMR, polarimetric and Mössbauer spectroscopic methods. The experimental results proved that deprotonation of D-fructose and L-sorbose is caused by the coordination of dimethyltin(IV)2+ in the unusual low pH interval 4-6 in contrast to the other saccharides deprotonated in analogous way at pH > 8. Increasing the pH of the solution resulted in the formation of further complexes. Stability and composition of the species was determined by potentiometric studies. 13C NMR measurements led to the assignment of the sugar OH groups participating in the processes. Mössbauer investigations in the quick-frozen solutions permitted the determination of the stereochemistry of tin(IV) in the complexes.

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