Unrelated viral suppressors of RNA silencing mediate the control of ARGONAUTE1 level

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Various plant viruses ubiquitously mediate the induction of miR168, resulting in the control of ARGONAUTE 1 (AGO1), which is the pivotal component of the microRNA (miRNA) regulation pathway and can also exhibit antiviral function. Here, we demonstrate that miR168-driven control of AGO1 can persist for a long time in virus-infected plants and can be an important component of symptom development. We also show that infection of RNA viruses belonging to various genera is associated with the transcriptional induction of the MIR168 precursor gene. Moreover, in a transient expression study, we reveal that different unrelated viral suppressors of RNA silencing (VSRs) are responsible for the enhanced accumulation of miR168. The induction of miR168 accumulation is an early function of VSRs and this activity is associated with the control of the endogenous AGO1 protein level. The common ability of unrelated VSRs to induce the miR168 level implies that this activity might be a component of the host defence suppression in plant-virus interactions.

Original languageEnglish
Pages (from-to)567-575
Number of pages9
JournalMolecular Plant Pathology
Volume14
Issue number6
DOIs
Publication statusPublished - Aug 2013

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Plant Viruses
plant viruses
Viral RNA
RNA Interference
RNA interference
RNA
virus
RNA Virus Infections
MicroRNAs
microRNA
Antiviral Agents
infection
Genes
protein
gene
Proteins
genes
proteins

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science
  • Soil Science
  • Molecular Biology

Cite this

Unrelated viral suppressors of RNA silencing mediate the control of ARGONAUTE1 level. / Várallyay, E.; Havelda, Z.

In: Molecular Plant Pathology, Vol. 14, No. 6, 08.2013, p. 567-575.

Research output: Contribution to journalArticle

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