Unprecedented diterpenoids as a PTP1B inhibitor from the hainan soft coral Sarcophyton trocheliophorum marenzeller

Lin Fu Liang, T. Kurtán, Attila Mándi, Li Gong Yao, Jia Li, Wen Zhang, Yue Wei Guo

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Methyl sarcotroates A and B (3 and 4), two unprecedented diterpenoids possessing a tetradecahydrocyclopenta[3′,4′]cyclobuta[1′, 2′:4,5]cyclonona[1,2-b]oxirene ring system, along with their probable biogenetic precursor, sarcophytonolide M (1), were isolated from the Hainan soft coral Sarcophyton trocheliophorum. Their structures were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 3 was determined by TDDFT ECD calculations. Compound 4 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), being similar to that of positive control oleanolic acid.

Original languageEnglish
Pages (from-to)274-277
Number of pages4
JournalOrganic Letters
Volume15
Issue number2
DOIs
Publication statusPublished - Jan 18 2013

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Non-Receptor Type 1 Protein Tyrosine Phosphatase
Oleanolic Acid
Anthozoa
phosphatases
Spectroscopic analysis
Diterpenes
tyrosine
spectroscopic analysis
inhibitors
proteins
acids
rings
configurations
oxirene

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Unprecedented diterpenoids as a PTP1B inhibitor from the hainan soft coral Sarcophyton trocheliophorum marenzeller. / Liang, Lin Fu; Kurtán, T.; Mándi, Attila; Yao, Li Gong; Li, Jia; Zhang, Wen; Guo, Yue Wei.

In: Organic Letters, Vol. 15, No. 2, 18.01.2013, p. 274-277.

Research output: Contribution to journalArticle

Liang, Lin Fu ; Kurtán, T. ; Mándi, Attila ; Yao, Li Gong ; Li, Jia ; Zhang, Wen ; Guo, Yue Wei. / Unprecedented diterpenoids as a PTP1B inhibitor from the hainan soft coral Sarcophyton trocheliophorum marenzeller. In: Organic Letters. 2013 ; Vol. 15, No. 2. pp. 274-277.
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