Unlike PPARgamma, neither other PPARs nor PGC-1alpha is elevated in the cerebrospinal fluid of patients with multiple sclerosis

Levente Szalardy, Denes Zadori, K. Bencsik, L. Vécsei, P. Klivényi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Corroborating with prior experimental findings, we recently reported the pronounced elevation of peroxisome proliferator-activated receptor gamma (PPARγ) protein concentration in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS), in association with neuroinflammatory markers and clinical severity. Based on subsequent reports on the possible involvement of other PPARs and PPARγ coactivator-1alpha (PGC-1α) in neuroinflammation in MS, we analyzed the protein levels of PPARα, PPARβ/δ, and PGC-1α in a subset of CSF samples from the same cohort of relapsing-remitting MS patients. Unlike PPARγ, none of these proteins were found elevated in MS patients (n = 25) compared to non-inflammatory controls (n = 16), with the levels of PPARα and PPARβ/δ found generally below the limit of detection, and that of PGC-1α being detectable but comparable in both groups. The clinical and laboratory associations previously reported with PPARγ were however significant even in this smaller subset. The potential underlying causes of these differential alterations are discussed. The findings suggest that despite their proposed involvement in the regulation of inflammatory processes in MS, PPARα, PPARβ/δ, and PGC-1α proteins are not potential biomarkers of neuroinflammation in MS, and indicate a preferential role of PPARγ in the endogenous regulation of autoimmune response in the human CNS within its receptor family.

Original languageEnglish
Pages (from-to)128-133
Number of pages6
JournalNeuroscience Letters
Volume651
DOIs
Publication statusPublished - Jun 9 2017

Fingerprint

Peroxisome Proliferator-Activated Receptors
PPAR gamma
Multiple Sclerosis
Cerebrospinal Fluid
Proteins
Biomarkers
Relapsing-Remitting Multiple Sclerosis
Autoimmunity
Limit of Detection

Keywords

  • Biomarker
  • Cerebrospinal fluid
  • ELISA
  • Multiple sclerosis
  • Peroxisome proliferator-activated receptor alpha
  • Peroxisome proliferator-activated receptor beta
  • Peroxisome proliferator-activated receptor gamma
  • Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Unlike PPARgamma, neither other PPARs nor PGC-1alpha is elevated in the cerebrospinal fluid of patients with multiple sclerosis. / Szalardy, Levente; Zadori, Denes; Bencsik, K.; Vécsei, L.; Klivényi, P.

In: Neuroscience Letters, Vol. 651, 09.06.2017, p. 128-133.

Research output: Contribution to journalArticle

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