Unique topographic separation of two spectral classes of cones in the mouse retina

A. Szél, P. Röhlich, A. R. Caffe, B. Juliusson, G. Aguirre, T. Van Veen

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

We have found two immunologically distinguishable cone types in the retina of the mouse, each localized to two opposite halves of the eye. One cone type was labelled by the monoclonal antibody COS-1 specific to the middle-to-long wave sensitive visual pigment of the mammals, while the other type was stained by the shortwave-specific monoclonal antibody (OS-2). These results were confirmed with other antibodies directed against specific sequences of the visual pigments. As a result of the uneven distribution of the two cone types the mouse retina is divided into two fields separated by an oblique meridional line. The middlewave sensitive cones were present exclusively in the dorsal half of the mouse retina (M-field). The overwhelming majority of the shortwave sensitive cones occupied the ventral half (S-field), and only a small number was scattered among the middlewave sensitive cones in the dorsal retina. The ratio of the two cone types in the M-field corresponds to what has been found in the retina of other mammals, including rodents such as the gerbil and the rat. The S-field represents an entirely unique area with the unusually great number of shortwave sensitive cones and with the complete lack of the middlewave sensitive ones. The present study provides the structural basis for dichromacy in a rodent species considered for a long time to be monochromat. In addition, it shows that the ventral retina, containing exclusively S-cones in a relatively high density, is a unique retinal field not present in other mammalian species studied so far.

Original languageEnglish
Pages (from-to)327-342
Number of pages16
JournalJournal of Comparative Neurology
Volume325
Issue number3
DOIs
Publication statusPublished - 1992

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Retina
Retinal Cone Photoreceptor Cells
Retinal Pigments
Mammals
Rodentia
Monoclonal Antibodies
Gerbillinae
Antibodies

Keywords

  • colour vision
  • cone distribution
  • immunocytochemistry
  • long wavelength cones
  • photoreceptor mosaic
  • rodents
  • short wavelength cones

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Unique topographic separation of two spectral classes of cones in the mouse retina. / Szél, A.; Röhlich, P.; Caffe, A. R.; Juliusson, B.; Aguirre, G.; Van Veen, T.

In: Journal of Comparative Neurology, Vol. 325, No. 3, 1992, p. 327-342.

Research output: Contribution to journalArticle

Szél, A. ; Röhlich, P. ; Caffe, A. R. ; Juliusson, B. ; Aguirre, G. ; Van Veen, T. / Unique topographic separation of two spectral classes of cones in the mouse retina. In: Journal of Comparative Neurology. 1992 ; Vol. 325, No. 3. pp. 327-342.
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