Unique Potentialities of Layer Liquid System-Results, Limitations, New Demands

Research output: Chapter in Book/Report/Conference proceedingChapter


Conventional layer liquid chromatographic techniques-practically, from paper chromatography through thin-layer chromatography (TLC) to high-performance thin-layer chromatography (HPTLC)-illustrated the unique potentialities of layer liquid systems. Formerly, these technical solutions based further advanced directions on layer liquid chromatography (LLC). However, the development of special adsorbent layers and eluent systems as well as separation chambers for TLC/HPTLC developments demanded innovative steps in chemical-instrumental technologies. Partial renewal of TLC (development of HPTLC) decreased the dimensions of the basic TLC and represents a certain progress in LLC. The automation and hyphenation, e.g., with modern spectroscopic techniques [such as TLC/HPTLC-MS (mass spectroscopy) or TLC/HPTLC-FTIR (Fourier transform infrared)] as well as multidimensional separations, illustrate the future horizons and further potential in LLC. The drawbacks of HPTLC (e.g., limited preparative applicability, limited spot capacity possibilities), as the most efficient technique among the conventional layer liquid chromatographic techniques, have resulted in claims for optimum eluent front velocity, which can be generated by using forced flow of the eluent.

Original languageEnglish
Title of host publicationForced-Flow Layer Chromatography
PublisherElsevier Inc.
Number of pages47
ISBN (Print)9780124201613
Publication statusPublished - 2016


  • Adsorbent layer
  • Automation
  • Development mode
  • Eluent
  • Forced flow
  • Fourier transform infrared (FTIR)
  • High-performance thin-layer chromatography (HPTLC)
  • Hyphenation
  • Layer liquid system
  • Mass spectroscopy (MS)
  • Mobile phase
  • Multidimensional
  • Optimum eluent front velocity
  • Separation chamber
  • Thin-layer chromatography (TLC)

ASJC Scopus subject areas

  • Chemistry(all)

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