Unique microRNA expression profiles in cervical cancer

Katalin Gocze, Katalin Gombos, Krisztina Juhasz, Krisztina Kovacs, Bela Kajtar, Marta Benczik, Peter Gocze, Balazs Patczai, Istvan Arany, I. Ember

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Cervical cancer is the second leading cause of death among female patients with cancer in the world. Our aim was to analyze cervical cancer cases, in the Southwestern Transdanubian Region of Hungary, with regard to human papillomavirus (HPV) genotype and histological and clinical grading. After HPV testing and genotyping, the expressions of eight different pre-microRNAs (miR-21, miR- 27a, miR-34a, miR-146a, miR-155, miR-196a, miR-203, miR-221) in formalin-fixed paraffin-embedded (FFPE) primary human cervical cancer samples were evaluated with the help of the LightCycler 480 PCR System (Roche). Statistically significant overexpression of miR-21 (p=0.004), miR-27a (p=0.018), miR-34a (p

Original languageEnglish
Pages (from-to)2561-2568
Number of pages8
JournalAnticancer Research
Volume33
Issue number6
Publication statusPublished - Jun 2013

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MicroRNAs
Uterine Cervical Neoplasms
Hungary
Paraffin
Formaldehyde
Cause of Death
Genotype
Polymerase Chain Reaction
Neoplasms

Keywords

  • Cervical cancer
  • Clinical grading
  • HPV
  • MicroRNA expression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gocze, K., Gombos, K., Juhasz, K., Kovacs, K., Kajtar, B., Benczik, M., ... Ember, I. (2013). Unique microRNA expression profiles in cervical cancer. Anticancer Research, 33(6), 2561-2568.

Unique microRNA expression profiles in cervical cancer. / Gocze, Katalin; Gombos, Katalin; Juhasz, Krisztina; Kovacs, Krisztina; Kajtar, Bela; Benczik, Marta; Gocze, Peter; Patczai, Balazs; Arany, Istvan; Ember, I.

In: Anticancer Research, Vol. 33, No. 6, 06.2013, p. 2561-2568.

Research output: Contribution to journalArticle

Gocze, K, Gombos, K, Juhasz, K, Kovacs, K, Kajtar, B, Benczik, M, Gocze, P, Patczai, B, Arany, I & Ember, I 2013, 'Unique microRNA expression profiles in cervical cancer', Anticancer Research, vol. 33, no. 6, pp. 2561-2568.
Gocze K, Gombos K, Juhasz K, Kovacs K, Kajtar B, Benczik M et al. Unique microRNA expression profiles in cervical cancer. Anticancer Research. 2013 Jun;33(6):2561-2568.
Gocze, Katalin ; Gombos, Katalin ; Juhasz, Krisztina ; Kovacs, Krisztina ; Kajtar, Bela ; Benczik, Marta ; Gocze, Peter ; Patczai, Balazs ; Arany, Istvan ; Ember, I. / Unique microRNA expression profiles in cervical cancer. In: Anticancer Research. 2013 ; Vol. 33, No. 6. pp. 2561-2568.
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