Unexpected insensitivity of the cholinergic motor responses to morphine in the human small intestine

Rita Benko, Zsuzsanna Molnár, Dániel Nemes, András Dékány, Dezsö Kelemen, Lászlo Illényi, Lászlo Cseke, András Papp, Gábor Varga, Loránd Bartho

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4 Citations (Scopus)

Abstract

Background/Aims: Morphine is known to inhibit cholinergic contractions of the guinea pig small intestine. This has been compared to the human small intestinal innervated longitudinal muscle in the current study. Methods: Cholinergic primary contractions of human small intestinal longitudinal strips were evoked by electrical field stimulation (EFS; 0.5-5 Hz in the presence of purinergic and nitrergic blockers or 5 Hz without pretreatment) and recorded isotonically in organ bath experiments. Guinea pig small intestinal segments were also studied. Results and Conclusion: Neurogenic cholinergic contractions of human preparations were unaffected by morphine (1, 2 or 10 μmol/l). Longitudinal contractions of the guinea pig ileum were concentration-dependently suppressed by morphine (0.1-10 μmol/l). It is concluded that myenteric neurons supplying the longitudinal muscle of the human small intestine are much less sensitive to morphine than those of the guinea pig.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalPharmacology
Volume86
Issue number3
DOIs
Publication statusPublished - Sep 1 2010

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Keywords

  • Acetylcholine
  • Cholinergic responses
  • Morphine
  • Neurogenic contraction
  • Opioid agonists
  • Small intestine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Benko, R., Molnár, Z., Nemes, D., Dékány, A., Kelemen, D., Illényi, L., Cseke, L., Papp, A., Varga, G., & Bartho, L. (2010). Unexpected insensitivity of the cholinergic motor responses to morphine in the human small intestine. Pharmacology, 86(3), 145-148. https://doi.org/10.1159/000316637