Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis

Leszek P. Pryszcz, Tibor Németh, Attila Gácser, Toni Gabaldón

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. It has been postulated that C. parapsilosis clinical isolates result from a recent global expansion of a virulent clone. However, the availability of a single genome for this species has so far prevented testing this hypothesis at genomic scales. We present here the sequence of three additional strains from clinical and environmental samples. Our analyses reveal unexpected patterns of genomic variation, shared among distant strains, that argue against the clonal expansion hypothesis. All strains carry independent expansions involving an arsenite transporter homolog, pointing to the existence of directional selection in the environment, and independent origins of the two clinical isolates. Furthermore, we report the first evidence for the existence of recombination in this species. Altogether, our results shednew light onto the dynamics of genome evolution in C. parapsilosis.

Original languageEnglish
Pages (from-to)2382-2392
Number of pages11
JournalGenome Biology and Evolution
Volume5
Issue number12
DOIs
Publication statusPublished - 2013

Keywords

  • Candida
  • Genome comparison
  • Pathogens
  • Recombination

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics

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