Undulating membraneous structures associated with the endoplasmic reticulum in tumour cells

Z. Schaff, K. Lapis, P. M. Grimley

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19 Citations (Scopus)

Abstract

The presence of membraneous structures with a tubular form associated with the endoplasmic reticulum has been described in a variety of cell types from a wide range of animals and from man, in both normal and pathologic conditions. In particular, these structures have frequently been observed in autoimmune and neoplastic diseases and in association with viral infections. Differences of opinion exist concerning the morphogenesis and organization of these structures, which are not always separated as discrete morphologic entities. Some authors think that they represent nucleocapsids of viruses, while others believe them to constitute the cellular reaction to such different factors as virus infection, antigenic effect or neoplastic proliferation. The purpose of this paper is to compare the morphology and occurrence of two characteristic types of inclusions closely associated with the endoplasmic reticulum in tumor cells, namely the tubuloreticular structures (TRS) and a formation herein designated as undulating membraneous structure (UMS). Both TRS and UMS were examined under normal and pathologic conditions. It was found that TRS and UMS are cytoplasmic inclusions of similar type but of different organization. The UMS in a human cell line derived from a carcinoma of the lung and in a transplantable chicken hepatoma derived from an MC 29 virus induced liver tumor are described.

Original languageEnglish
Pages (from-to)697-702
Number of pages6
JournalInternational Journal of Cancer
Volume18
Issue number5
Publication statusPublished - 1976

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Virus Diseases
Endoplasmic Reticulum
Viruses
Nucleocapsid
Inclusion Bodies
Morphogenesis
Autoimmune Diseases
Hepatocellular Carcinoma
Chickens
Neoplasms
Carcinoma
Cell Line
Lung
Liver

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Undulating membraneous structures associated with the endoplasmic reticulum in tumour cells. / Schaff, Z.; Lapis, K.; Grimley, P. M.

In: International Journal of Cancer, Vol. 18, No. 5, 1976, p. 697-702.

Research output: Contribution to journalArticle

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