Under-expression of CD24 in pre-eclamptic placental tissues determined by quantitative real-time RT-PCR

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3 Citations (Scopus)

Abstract

Background: Pre-eclampsia is a pregnancy-related disorder present in about 5-7% of all pregnancies. CD24 expression was recently reported in different diseases, while it has not yet been determined in pre-eclamptic placental tissues. Methods: We collected placental tissues from pre-eclamptic (n = 16) and healthy pregnancies (n = 16). We used the quantitative real-time PCR method with a primer-probe system for determination of CD24 gene expression. Results: We measured CD24 concentrations of 18.94 ± 26.86 ng/μl in the pre-eclamptic and 53.85 ± 92.05 ng/μl in the healthy placental tissues (p = 0.03). Conclusions: The quantitative real-time PCR method is suitable to determine CD24 expression in placental tissues. We suppose the low expression of CD24 may cause the enhanced immune reaction and could play a role in the abnormal development of placenta in pre-eclampsia.

Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalFetal Diagnosis and Therapy
Volume23
Issue number4
DOIs
Publication statusPublished - Apr 1 2008

Keywords

  • CD24
  • Gene expression
  • Placenta
  • Pre-eclampsia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynaecology

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