Ultrastructural localization of somatostatin- and substance P-immunoreactive nerve fibers in the feline liver

E. Fehér, Mariann Fodor, J. Fehér

Research output: Contribution to journalArticle

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Abstract

The distribution and the possible source of somatostatin- and substance P-immunoreactive nerve fibers were studied in the liver of the cat by immunocytochemical techniques. Abundant substance P-immunoreactive and a moderate number of somatostatin-immunoreactive nerve fibers were found running around the blood vessels in the perilobular connective tissue. Some somatostatin-immunoreactive nerve cell bodies were also observed in the liver. A moderate number of somatostatin-immunoreactive nerve profiles were found inside the hepatic lobules along the sinusoid endothelial cells and the hepatocytes. The interspace between the axon and hepatocyte and endothelial cells membranes was about 20 nm. Cutting the extrinsic hepatic nerves resulted in marked reduction of substance P-immunoreactive nerves but only a slight reduction of somatostatin-immunoreactive nerves in the liver. These findings provide a morphological basis for the possibility that somatostatin and substance P may act as transmitters or neuromodulators on the neighboring smooth muscle cells of vessels and may regulate the function of the hepatocytes. It is also possible that some of these fibers serve sensory function along the blood vessels.

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalGastroenterology
Volume102
Issue number1
Publication statusPublished - 1992

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Felidae
Substance P
Somatostatin
Nerve Fibers
Liver
Hepatocytes
Blood Vessels
Endothelial Cells
Running
Connective Tissue
Smooth Muscle Myocytes
Neurotransmitter Agents
Axons
Cats
Cell Membrane
Neurons

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ultrastructural localization of somatostatin- and substance P-immunoreactive nerve fibers in the feline liver. / Fehér, E.; Fodor, Mariann; Fehér, J.

In: Gastroenterology, Vol. 102, No. 1, 1992, p. 287-294.

Research output: Contribution to journalArticle

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