Ultrastructural localisation of substance P, vasoactive intestinal polypeptide, somatostatin and neuropeptide Y immunoreactivity in perivascular nerve plexuses of the gut

E. Fehér, G. Burnslock

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Substance P, vasoactive intestinal polypeptide, somatostatin and neuropeptide Y-Like immunoreactivity was studied by immunocytochemistry in the wall of the blood vessels of the small intestine of the cat, rat and guinea-pig. Immunoreactive nerve fibres were localized by means of the peroxidase-antiperoxidase (PAP) procedure, by use of antisera raised against these peptides. These neuropeptide-containing nerve fibres were widespread in association with the blood vessels and especially with the dense network of perivascular nerves supplying arterioles. At the ultrastructural level, immunoreactive nerve fibres were found very close to the basement membrane of the capillary walls. No immunoreactive nerve fibres were found in the wall of the veins. The anatomical findings of the present study are consistent with the proposal that several neuropeptides could function as neurotransmitters or neuromodulators in the control of blood flow in the small intestine.

Original languageEnglish
Pages (from-to)125-136
Number of pages12
JournalJournal of Vascular Research
Volume23
Issue number3
DOIs
Publication statusPublished - 1986

Fingerprint

Neuropeptide Y
Vasoactive Intestinal Peptide
Substance P
Somatostatin
Nerve Fibers
Neuropeptides
Small Intestine
Neurotransmitter Agents
Blood Vessels
Arterioles
Basement Membrane
Peroxidase
Immune Sera
Veins
Guinea Pigs
Cats
Immunohistochemistry
Peptides

Keywords

  • Intestinal polypeptide, vasoactive
  • Neuropeptide
  • Small intestine
  • Somatostatin
  • Substance P

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "Substance P, vasoactive intestinal polypeptide, somatostatin and neuropeptide Y-Like immunoreactivity was studied by immunocytochemistry in the wall of the blood vessels of the small intestine of the cat, rat and guinea-pig. Immunoreactive nerve fibres were localized by means of the peroxidase-antiperoxidase (PAP) procedure, by use of antisera raised against these peptides. These neuropeptide-containing nerve fibres were widespread in association with the blood vessels and especially with the dense network of perivascular nerves supplying arterioles. At the ultrastructural level, immunoreactive nerve fibres were found very close to the basement membrane of the capillary walls. No immunoreactive nerve fibres were found in the wall of the veins. The anatomical findings of the present study are consistent with the proposal that several neuropeptides could function as neurotransmitters or neuromodulators in the control of blood flow in the small intestine.",
keywords = "Intestinal polypeptide, vasoactive, Neuropeptide, Small intestine, Somatostatin, Substance P",
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T1 - Ultrastructural localisation of substance P, vasoactive intestinal polypeptide, somatostatin and neuropeptide Y immunoreactivity in perivascular nerve plexuses of the gut

AU - Fehér, E.

AU - Burnslock, G.

PY - 1986

Y1 - 1986

N2 - Substance P, vasoactive intestinal polypeptide, somatostatin and neuropeptide Y-Like immunoreactivity was studied by immunocytochemistry in the wall of the blood vessels of the small intestine of the cat, rat and guinea-pig. Immunoreactive nerve fibres were localized by means of the peroxidase-antiperoxidase (PAP) procedure, by use of antisera raised against these peptides. These neuropeptide-containing nerve fibres were widespread in association with the blood vessels and especially with the dense network of perivascular nerves supplying arterioles. At the ultrastructural level, immunoreactive nerve fibres were found very close to the basement membrane of the capillary walls. No immunoreactive nerve fibres were found in the wall of the veins. The anatomical findings of the present study are consistent with the proposal that several neuropeptides could function as neurotransmitters or neuromodulators in the control of blood flow in the small intestine.

AB - Substance P, vasoactive intestinal polypeptide, somatostatin and neuropeptide Y-Like immunoreactivity was studied by immunocytochemistry in the wall of the blood vessels of the small intestine of the cat, rat and guinea-pig. Immunoreactive nerve fibres were localized by means of the peroxidase-antiperoxidase (PAP) procedure, by use of antisera raised against these peptides. These neuropeptide-containing nerve fibres were widespread in association with the blood vessels and especially with the dense network of perivascular nerves supplying arterioles. At the ultrastructural level, immunoreactive nerve fibres were found very close to the basement membrane of the capillary walls. No immunoreactive nerve fibres were found in the wall of the veins. The anatomical findings of the present study are consistent with the proposal that several neuropeptides could function as neurotransmitters or neuromodulators in the control of blood flow in the small intestine.

KW - Intestinal polypeptide, vasoactive

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KW - Somatostatin

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