Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia

P. Milner, V. Ralevic, A. M. Hopwood, E. Fehér, J. Lincoln, K. A. Kirkpatrick, G. Burnstock

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Substance P and choline acetyltransferase have been localised in a small proportion of endothelial cells of rat coronary arteries using electron microscopic immunocytochemistry. During a hypoxic period of 1 min, coronary vasodilatation was produced in the Langendorff heart preparation and increased levels of substance P and acetylcholine were released into the perfusate. The possibility that these substances are released from endothelial cells during hypoxia and contribute to the hyperaemic response is discussed.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalExperientia
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 1 1989

Keywords

  • Heart
  • acetylcholine
  • endothelial cells
  • hypoxia
  • substance P
  • ultrastructure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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