Ultrastructural, Lectin Histochemical and Immunohistological Observations on Merkel Cell Tumors

L. Pajor, M. Balázs, J. Balogh, F. Brittig, L. Joös, R. Linse, M. Scholz, Zs Suba, P. Töth

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The clinicopathological and ultrastructural findings of 10 cases of Merkel cell tumor (MCT) are presented. Three patients died rapidly due to tumor dissemination. The tumor cells in eight out of the 10 cases were positive for neuron-specific enolase, however, all were negative for the ten polypeptide hormones examined, as well as for the argentaffin and argyrophil reactions. One of the patients had suffered from chronic lymphocytic leukaemia. Particularly in this case, but also in the others, the differentiation of MCT from a malignant lymphoma necessitated immuno-histological, lectin histochemical and ultrastructural studies. The focal peanut agglutinin positivity of the tumor cells in 6 out of the 10 MCTs seems to be a characteristic feature of these cells.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalPathology Research and Practice
Volume181
Issue number1
DOIs
Publication statusPublished - Jan 1 1986

Keywords

  • Differential diagnosis
  • Merkel cell tumor
  • Neuron-specific enolase
  • Peanut agglutinin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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  • Cite this

    Pajor, L., Balázs, M., Balogh, J., Brittig, F., Joös, L., Linse, R., Scholz, M., Suba, Z., & Töth, P. (1986). Ultrastructural, Lectin Histochemical and Immunohistological Observations on Merkel Cell Tumors. Pathology Research and Practice, 181(1), 45-49. https://doi.org/10.1016/S0344-0338(86)80186-8