Ultrastructural investigations of finger pulp biopsies

A study of 31 patients with raynaud's syndrome

Katalin Vajda, A. Kádár, A. Kali, L. Urai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Finger pulp biopsies of 31 patients suffering from Raynaud's syndrome (RS) were investigated by light and electron microscopy. The patients suffered from various underlying diseases. Interest was focused on the vascular changes and nerve and connective tissue alterations, especially the elastic fiber changes. In the dermal capillaries, endothelial swelling, narrowing of the lumen, increased numbers of intracytoplasmic filaments and Weibel-Palade bodies, and various types of basement membrane alterations were observed. The basement membrane of the unmyelinated nerves showed similar alterations to the capillary basement membrane. Severe degenerative changes were found in the myelin sheath of the myelinated axons. In the dermal connective tissue, severe elastotic degeneration and alterations of the collagen fibers were observed. The data probably represent the ultrastructural picture of the end stage of this syndrome.

Original languageEnglish
Pages (from-to)175-186
Number of pages12
JournalUltrastructural Pathology
Volume3
Issue number2
DOIs
Publication statusPublished - 1982

Fingerprint

Biopsy
Basement Membrane
Fingers
Pulp
basements
connective tissue
Connective Tissue
nerves
membranes
Weibel-Palade Bodies
Tissue
Nerve Tissue
Somatotypes
Skin
myelin sheath
Elastic Tissue
Fibers
Myelin Sheath
axons
Collagen

Keywords

  • Basement membrane
  • Elastotic degeneration
  • Electron microscopy
  • Peripheral nerve alteration
  • Raynaud's syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology
  • Instrumentation

Cite this

Ultrastructural investigations of finger pulp biopsies : A study of 31 patients with raynaud's syndrome. / Vajda, Katalin; Kádár, A.; Kali, A.; Urai, L.

In: Ultrastructural Pathology, Vol. 3, No. 2, 1982, p. 175-186.

Research output: Contribution to journalArticle

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