Ultrastructural immunogold studies in two cases of linear IgA dermatosis. Are there two distinct types of this disease?

S. Kárpáti, W. Stolz, M. Meurer, T. Krieg, O. Braun-Falco

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Abstract

It has been suggested that patients with homogeneous linear IgA deposits at the basement membrane zone constitute a distinct bullous disorder called linear IgA dermatosis (LAD) of adults or children. The results of the present ultrastructural immunogold study in two patients with LAD suggest that LAD is not a single disease entity. LAD in a 10-year-old girl was found to be ultrastructurally similar to an IgA-type pemphigoid. IgA was detected in the uppermost lamina lucida underlying the basal cell plasma membrane. In a second patient, an 86-year-old man, IgA deposits were present within the lamina densa and the anchoring plaques. The distribution of IgA in this patient was ultrastructurally identical with that of IgG in epidermolysis bullosa acquisita skin and with that of the non-collagenous globular terminus of collagen VII within the basement membrane zone of normal skin. By using the immunogold technique, we could distinguish two distinct types of LAD according to the IgA binding sites in the diseased skin. We suggest that different labelling patterns may correspond to different clinical pictures.

Original languageEnglish
Pages (from-to)112-118
Number of pages7
JournalBritish Journal of Dermatology
Volume127
Issue number2
DOIs
Publication statusPublished - 1992

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Linear IgA Bullous Dermatosis
Immunoglobulin A
Basement Membrane
Epidermolysis Bullosa Acquisita
Cell Membrane
Bullous Pemphigoid
Skin
Skin Diseases
Collagen
Immunoglobulin G
Immunohistochemistry
Binding Sites

ASJC Scopus subject areas

  • Dermatology

Cite this

Ultrastructural immunogold studies in two cases of linear IgA dermatosis. Are there two distinct types of this disease? / Kárpáti, S.; Stolz, W.; Meurer, M.; Krieg, T.; Braun-Falco, O.

In: British Journal of Dermatology, Vol. 127, No. 2, 1992, p. 112-118.

Research output: Contribution to journalArticle

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