Ultrastructural features of primate granule cell bodies show important differences from those of rats: axosomatic synapses, somatic spines and infolded nuclei

László Seress, Charles E. Ribak

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Granule cells of the primate dentate gyrus were examined in the electron microscope where they displayed significantly less axosomatic synapses than granule cells in rodents. In addition, primate granule cells frequently had infolded cell nuclei and somal spines which are features that are both rare in rodents. Since the granule cell body is an important site for γ-aminobutyric acid (GABA)ergic inhibitory control, the reduced number of axosomatic synapses in monkeys suggests that local inhibitory connections of primate granule cells are less than that of rodents. Together, these differences may indicate that the primate granule cells are physiologically more active than rat granule cells.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalBrain research
Volume569
Issue number2
DOIs
Publication statusPublished - Jan 13 1992

Keywords

  • Granule cell
  • Hippocampus
  • Monkey
  • Somal synapse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Ultrastructural features of primate granule cell bodies show important differences from those of rats: axosomatic synapses, somatic spines and infolded nuclei'. Together they form a unique fingerprint.

  • Cite this