Ultrastructural elements in experimental intimal thickening. II. Study of the development of elastic elements in intimal proliferation

A. Kádár, B. Veress, H. Jellinek

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Abstract

The ultrastructure of elastic elements and other extracellular substances was examined in experimental intimal thickening produced under conditions described in the first part of this series. It seems that the precursor of the elastic fibers is produced by the young smooth muscle cells constituting the intimal thickening. The precursor, which may be identical with desmosin, acquires further components from mucopolysaccharide filaments of the basement membrane and forms the elastic granules of 70-Å diameter. In the extracellular space the elastic granules unite to form elastic fibrils of 140-Å periodicity, which partly by linking with each other, partly by embedding in mucopolysaccharide, give rise to elastic clumps of 0.04 - 0.2-μ diameter. Finally, the elastic fibers arise by fusion of the elastic clumps. The basement membrane of the smooth muscle cells seems to have a close relationship with elastic fiber formation. The dissimilar PTA-binding ability of the various elastic elements has been a matter of controversy in the literature; the hypothetical explanation offered in this study remains to be confirmed.

Original languageEnglish
Pages (from-to)212-223
Number of pages12
JournalExperimental and Molecular Pathology
Volume11
Issue number2
Publication statusPublished - Oct 1969

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Tunica Intima
Elastic Tissue
Glycosaminoglycans
Basement Membrane
Smooth Muscle Myocytes
Muscle
Fibers
Cells
Extracellular Space
Periodicity
Fusion reactions

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Ultrastructural elements in experimental intimal thickening. II. Study of the development of elastic elements in intimal proliferation. / Kádár, A.; Veress, B.; Jellinek, H.

In: Experimental and Molecular Pathology, Vol. 11, No. 2, 10.1969, p. 212-223.

Research output: Contribution to journalArticle

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