Ultrastructural effects of parachlorophenylalanine, 5-hydroxytryptamine and the imipramine group on the nerve processes of the small intestine

Erzsébet Feher, Kâroly Csânyi

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Abstract

The structure of the nerve fibres in the chronically isolated cat ileum was studied by fluorescence and electron microscopy after imiprarnine grouP compounds, parachloro-phenylalanine. and 5-hydroxytryptamine treatment. Follwing treatment with parachloro-phenylalanine and imipramine group compounds in the nerve fibres ol the sma intestine, specific granules were selectively decreased (p<0.001) in number. In concordance with ultra-structural observations, a marked diminution of fluorescence intensity vvas demonstra le in the small intestine. In addition, the number of the granular vesicles was significant y increased following 5-hydroxytryptamine treatment, and yellow fluorescent neurones and processes were observed in the myenteric and submucous plexuses. On the basis of these observations, the serotoninergic nature of certain nerve fibres could be demons1 rated.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalCells Tissues Organs
Volume100
Issue number1
DOIs
Publication statusPublished - Jan 1 1978

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Keywords

  • Autonomic nervous system
  • Cat
  • Small intestine

ASJC Scopus subject areas

  • Anatomy
  • Histology

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