Ultrastructural binding sites of endomysium antibodies from sera of patients with dermatitis herpetiformis and coeliac disease

S. Kárpáti, M. Meurer, W. Stolz, A. Bürgin-Wolff, O. Braun-Falco, T. Krieg

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The ultrastructural binding sites of endomysium antibodies, specific serological markers of gluten sensitive enteropathy, were investigated in the rabbit oesophagus using the immunogold technique. Endomysium antibodies from sera of patients with dermatitis herpetiformis and with coeliac disease bound in an identical manner in a non-fibrillar material closely associated with fine collagenous-reticulin fibrils and also with similar fibrils connecting smooth muscle cells and elastic tissue in the endomysial connective tissue. These observations suggest that IgA antibodies in sera from patients with dermatitis herpetiformis and coeliac disease recognise a common antigen in an amorphous component associated with the reticular connective tissue of oesophageal lamina muscularis mucosae and thus confirm the probable identity of IgA class endomysium and jejunal antibodies.

Original languageEnglish
Pages (from-to)191-193
Number of pages3
JournalGut
Volume33
Issue number2
Publication statusPublished - Feb 1992

Fingerprint

Antibody Binding Sites
Dermatitis Herpetiformis
Celiac Disease
Connective Tissue
Immunoglobulin A
Antibodies
Serum
Reticulin
Elastic Tissue
Esophagus
Smooth Muscle Myocytes
Mucous Membrane
Immunohistochemistry
Rabbits
Antigens
Muscles

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kárpáti, S., Meurer, M., Stolz, W., Bürgin-Wolff, A., Braun-Falco, O., & Krieg, T. (1992). Ultrastructural binding sites of endomysium antibodies from sera of patients with dermatitis herpetiformis and coeliac disease. Gut, 33(2), 191-193.

Ultrastructural binding sites of endomysium antibodies from sera of patients with dermatitis herpetiformis and coeliac disease. / Kárpáti, S.; Meurer, M.; Stolz, W.; Bürgin-Wolff, A.; Braun-Falco, O.; Krieg, T.

In: Gut, Vol. 33, No. 2, 02.1992, p. 191-193.

Research output: Contribution to journalArticle

Kárpáti, S, Meurer, M, Stolz, W, Bürgin-Wolff, A, Braun-Falco, O & Krieg, T 1992, 'Ultrastructural binding sites of endomysium antibodies from sera of patients with dermatitis herpetiformis and coeliac disease', Gut, vol. 33, no. 2, pp. 191-193.
Kárpáti, S. ; Meurer, M. ; Stolz, W. ; Bürgin-Wolff, A. ; Braun-Falco, O. ; Krieg, T. / Ultrastructural binding sites of endomysium antibodies from sera of patients with dermatitis herpetiformis and coeliac disease. In: Gut. 1992 ; Vol. 33, No. 2. pp. 191-193.
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