Ultrastructural analysis of experimentally induced invasion in the rat lung by tumor cells metastasizing lymphatically.

S. Paku, N. Paweletz, E. Spiess, P. Aulenbacher, H. O. Werling, M. Knierim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The colonization of the lung by the rat tumor cells BSp73 ASML which have the ability to metastasize via the lymphatic system was studied at the ultrastructural level. Tumor cells arriving in the lung after i.v. injection become transiently embolized; within hours, however, they begin to extravasate from the blood capillaries. Swelling cellular protrusions open a limited area between endothelium and basal lamina through which tumor cells erupt. Tumor cells then form metastases in the interstitial tissue and, in an apparently lymphotropic action, intravasate the lymphatic vessels in a similar manner to a reverse diapedesis-like process. Within the lympatic system they settle, spread, and build up extensive tumor foci particularly in the subpleural region.

Original languageEnglish
Pages (from-to)957-966
Number of pages10
JournalAnticancer Research
Volume6
Issue number5
Publication statusPublished - Sep 1986

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Lung
Neoplasms
Cell Surface Extensions
Transendothelial and Transepithelial Migration
Lymphatic System
Lymphatic Vessels
Basement Membrane
Endothelium
Neoplasm Metastasis
Injections

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Paku, S., Paweletz, N., Spiess, E., Aulenbacher, P., Werling, H. O., & Knierim, M. (1986). Ultrastructural analysis of experimentally induced invasion in the rat lung by tumor cells metastasizing lymphatically. Anticancer Research, 6(5), 957-966.

Ultrastructural analysis of experimentally induced invasion in the rat lung by tumor cells metastasizing lymphatically. / Paku, S.; Paweletz, N.; Spiess, E.; Aulenbacher, P.; Werling, H. O.; Knierim, M.

In: Anticancer Research, Vol. 6, No. 5, 09.1986, p. 957-966.

Research output: Contribution to journalArticle

Paku, S, Paweletz, N, Spiess, E, Aulenbacher, P, Werling, HO & Knierim, M 1986, 'Ultrastructural analysis of experimentally induced invasion in the rat lung by tumor cells metastasizing lymphatically.', Anticancer Research, vol. 6, no. 5, pp. 957-966.
Paku, S. ; Paweletz, N. ; Spiess, E. ; Aulenbacher, P. ; Werling, H. O. ; Knierim, M. / Ultrastructural analysis of experimentally induced invasion in the rat lung by tumor cells metastasizing lymphatically. In: Anticancer Research. 1986 ; Vol. 6, No. 5. pp. 957-966.
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