Ultrastructural alterations in the initial segments and in the recurrent collateral terminals of Purkinje cells following axotomy

József Hámori, István Lakos

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14 Citations (Scopus)

Abstract

Transection of Purkinje cell axons in adult male rats made 1.5 mm or further from the cell body does not lead to the death of the neuron and results in compensatory structural alterations of the surviving axonal portions of the nerve cell. Near to, and at the emergence of recurrent collaterals of Purkinje cell axons, huge varicosities filled with filaments, granular material, lysosomes and mitochondria develop. Terminals of recurrent axon collaterals also exhibit different degrees of structural changes. Most striking of the morphological alterations is the regular presence of nematosomes in the hypertrophic axonal branches, especially in synaptic terminals. Since nematosomes were shown to contain RNA in other types of neurons, their presence in recurrent collaterals may indicate an enhanced synthetic activity in Purkinje axonal processes and endings after axotomy.

Original languageEnglish
Pages (from-to)415-427
Number of pages13
JournalCell And Tissue Research
Volume212
Issue number3
DOIs
Publication statusPublished - Nov 1 1980

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Keywords

  • Axotomy
  • Cerebellum
  • Purkinje axon
  • Rat
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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