Ultrastructural alterations in the initial segments and in the recurrent collateral terminals of Purkinje cells following axotomy

J. Hámori, István Lakos

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Transection of Purkinje cell axons in adult male rats made 1.5 mm or further from the cell body does not lead to the death of the neuron and results in compensatory structural alterations of the surviving axonal portions of the nerve cell. Near to, and at the emergence of recurrent collaterals of Purkinje cell axons, huge varicosities filled with filaments, granular material, lysosomes and mitochondria develop. Terminals of recurrent axon collaterals also exhibit different degrees of structural changes. Most striking of the morphological alterations is the regular presence of nematosomes in the hypertrophic axonal branches, especially in synaptic terminals. Since nematosomes were shown to contain RNA in other types of neurons, their presence in recurrent collaterals may indicate an enhanced synthetic activity in Purkinje axonal processes and endings after axotomy.

Original languageEnglish
Pages (from-to)415-427
Number of pages13
JournalCell and Tissue Research
Volume212
Issue number3
DOIs
Publication statusPublished - Nov 1980

Fingerprint

Axotomy
Purkinje Cells
Neurons
Presynaptic Terminals
Axons
Mitochondria
Granular materials
Lysosomes
Rats
Cells
RNA

Keywords

  • Axotomy
  • Cerebellum
  • Purkinje axon
  • Rat
  • Ultrastructure

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

Cite this

Ultrastructural alterations in the initial segments and in the recurrent collateral terminals of Purkinje cells following axotomy. / Hámori, J.; Lakos, István.

In: Cell and Tissue Research, Vol. 212, No. 3, 11.1980, p. 415-427.

Research output: Contribution to journalArticle

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