Ulcerative proctitis

A review of pharmacotherapy and management

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Ulcerative proctitis (UP) is a common presentation of ulcerative colitis (UC). Objective: To summarize available literature on up-to-date management and pharmacotherapy of UP patients. Methods: Extensive Medline/Embase literature search was performed to identify relevant articles. Results/conclusion: Topical medication with rectally administered 5-aminosalicylic acid (5-ASA)/corticosteroid suppositories or enemas is effective treatment for most UP patients. Locally administered 5-ASA is more efficacious than oral compounds. The combination of topical 5-ASA and oral 5-ASA or topical steroids should be considered for escalation of treatment. Maintenance treatment is indicated in all UC cases. 5-ASA suppositories are suggested as first-line maintenance therapy if accepted by patients, although oral 5-ASA as maintenance therapy might prevent proximal extension of the disease. After re-assessment, chronically active patients refractory or intolerant to 5-ASAs and corticosteroids may require immunomodulators or biological therapy. Exceptional cases may require a proctocolectomy.

Original languageEnglish
Pages (from-to)741-749
Number of pages9
JournalExpert Opinion on Pharmacotherapy
Volume9
Issue number5
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Proctitis
Mesalamine
Drug Therapy
Suppositories
Ulcerative Colitis
Adrenal Cortex Hormones
Therapeutics
Biological Therapy
Enema
Immunologic Factors
Steroids

Keywords

  • 5-ASA
  • Azathioprine
  • Infliximab
  • Steroids
  • Therapy
  • Ulcerative colitis
  • Ulcerative proctitis

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Ulcerative proctitis : A review of pharmacotherapy and management. / Lakatos, P.; Lakatos, L.

In: Expert Opinion on Pharmacotherapy, Vol. 9, No. 5, 04.2008, p. 741-749.

Research output: Contribution to journalArticle

@article{76492d69576640c0b2812c280a695463,
title = "Ulcerative proctitis: A review of pharmacotherapy and management",
abstract = "Background: Ulcerative proctitis (UP) is a common presentation of ulcerative colitis (UC). Objective: To summarize available literature on up-to-date management and pharmacotherapy of UP patients. Methods: Extensive Medline/Embase literature search was performed to identify relevant articles. Results/conclusion: Topical medication with rectally administered 5-aminosalicylic acid (5-ASA)/corticosteroid suppositories or enemas is effective treatment for most UP patients. Locally administered 5-ASA is more efficacious than oral compounds. The combination of topical 5-ASA and oral 5-ASA or topical steroids should be considered for escalation of treatment. Maintenance treatment is indicated in all UC cases. 5-ASA suppositories are suggested as first-line maintenance therapy if accepted by patients, although oral 5-ASA as maintenance therapy might prevent proximal extension of the disease. After re-assessment, chronically active patients refractory or intolerant to 5-ASAs and corticosteroids may require immunomodulators or biological therapy. Exceptional cases may require a proctocolectomy.",
keywords = "5-ASA, Azathioprine, Infliximab, Steroids, Therapy, Ulcerative colitis, Ulcerative proctitis",
author = "P. Lakatos and L. Lakatos",
year = "2008",
month = "4",
doi = "10.1517/14656566.9.5.741",
language = "English",
volume = "9",
pages = "741--749",
journal = "Expert Opinion on Pharmacotherapy",
issn = "1465-6566",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Ulcerative proctitis

T2 - A review of pharmacotherapy and management

AU - Lakatos, P.

AU - Lakatos, L.

PY - 2008/4

Y1 - 2008/4

N2 - Background: Ulcerative proctitis (UP) is a common presentation of ulcerative colitis (UC). Objective: To summarize available literature on up-to-date management and pharmacotherapy of UP patients. Methods: Extensive Medline/Embase literature search was performed to identify relevant articles. Results/conclusion: Topical medication with rectally administered 5-aminosalicylic acid (5-ASA)/corticosteroid suppositories or enemas is effective treatment for most UP patients. Locally administered 5-ASA is more efficacious than oral compounds. The combination of topical 5-ASA and oral 5-ASA or topical steroids should be considered for escalation of treatment. Maintenance treatment is indicated in all UC cases. 5-ASA suppositories are suggested as first-line maintenance therapy if accepted by patients, although oral 5-ASA as maintenance therapy might prevent proximal extension of the disease. After re-assessment, chronically active patients refractory or intolerant to 5-ASAs and corticosteroids may require immunomodulators or biological therapy. Exceptional cases may require a proctocolectomy.

AB - Background: Ulcerative proctitis (UP) is a common presentation of ulcerative colitis (UC). Objective: To summarize available literature on up-to-date management and pharmacotherapy of UP patients. Methods: Extensive Medline/Embase literature search was performed to identify relevant articles. Results/conclusion: Topical medication with rectally administered 5-aminosalicylic acid (5-ASA)/corticosteroid suppositories or enemas is effective treatment for most UP patients. Locally administered 5-ASA is more efficacious than oral compounds. The combination of topical 5-ASA and oral 5-ASA or topical steroids should be considered for escalation of treatment. Maintenance treatment is indicated in all UC cases. 5-ASA suppositories are suggested as first-line maintenance therapy if accepted by patients, although oral 5-ASA as maintenance therapy might prevent proximal extension of the disease. After re-assessment, chronically active patients refractory or intolerant to 5-ASAs and corticosteroids may require immunomodulators or biological therapy. Exceptional cases may require a proctocolectomy.

KW - 5-ASA

KW - Azathioprine

KW - Infliximab

KW - Steroids

KW - Therapy

KW - Ulcerative colitis

KW - Ulcerative proctitis

UR - http://www.scopus.com/inward/record.url?scp=41949134167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41949134167&partnerID=8YFLogxK

U2 - 10.1517/14656566.9.5.741

DO - 10.1517/14656566.9.5.741

M3 - Article

VL - 9

SP - 741

EP - 749

JO - Expert Opinion on Pharmacotherapy

JF - Expert Opinion on Pharmacotherapy

SN - 1465-6566

IS - 5

ER -