Types and spatial distribution of vasoactive intestinal polypeptide (VIP)-containing synapses in the rat visual cortex

Ferenc Hajós, Karl Zilles, Axel Schleicher, M. Kálmán

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

In the rat visual cortex vasoactive intestinal polypeptide (VIP)-containing structures were studied by means of light and electron microscopy and image analysis. VIP-immunoreactive axon terminals were found to form symmetric synapses with small dendritic shafts, dendritic spines and somata of pyramidal cells and interneurons. VIP-terminals often occured in pairs with VIP-negative, asymmetric synapses on the same postsynaptic structure. VIP-immunostained dendrites and perikarya were contacted by a purely asymmetric and a mixed population of VIP-negative terminals, respectively. Synaptic connections between two VIP-neurons are seldom as compared to the other types of VIP-synapses. Quantitative studies obtained by the image analysis of VIP-stained boutons and dendritic particles in light microscopic preparations suggest a distinct laminar distribution. Dendritic particles are most frequent in layers I-II, whereas axonal boutons have three laminar accumulations: at the border of layers I-II, in layer IV and layer VI. Together with previous results, the present findings argue for a non-random spatial distribution of VIP-boutons.

Original languageEnglish
Pages (from-to)207-217
Number of pages11
JournalAnatomy and Embryology
Volume178
Issue number3
DOIs
Publication statusPublished - Jun 1988

Fingerprint

Vasoactive Intestinal Peptide
Visual Cortex
Synapses
Light
Dendritic Spines
Pyramidal Cells
Presynaptic Terminals
Carisoprodol
Interneurons
Dendrites
Electron Microscopy
Neurons

Keywords

  • Rat
  • Spatial distribution
  • Synapse
  • VIP
  • Visual cortex

ASJC Scopus subject areas

  • Embryology
  • Anatomy
  • Developmental Biology
  • Cell Biology

Cite this

Types and spatial distribution of vasoactive intestinal polypeptide (VIP)-containing synapses in the rat visual cortex. / Hajós, Ferenc; Zilles, Karl; Schleicher, Axel; Kálmán, M.

In: Anatomy and Embryology, Vol. 178, No. 3, 06.1988, p. 207-217.

Research output: Contribution to journalArticle

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